Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia

Severe aplastic anemia (SAA) is an immune-mediated bone marrow failure characterized by pancytopenia. This study was aimed at uncovering proteins of plasma that were differentially expressed in SAA patients. 8 SAA patients and 8 health controls were enrolled and detected by data independent acquisit...

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Autores principales: Qi, Weiwei, Zhang, Yu, Yang, Wenhao, Liu, Chunyan, Wang, Huaquan, Fu, Rong, Shao, Zonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106528/
https://www.ncbi.nlm.nih.gov/pubmed/35571618
http://dx.doi.org/10.1155/2022/3700691
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author Qi, Weiwei
Zhang, Yu
Yang, Wenhao
Liu, Chunyan
Wang, Huaquan
Fu, Rong
Shao, Zonghong
author_facet Qi, Weiwei
Zhang, Yu
Yang, Wenhao
Liu, Chunyan
Wang, Huaquan
Fu, Rong
Shao, Zonghong
author_sort Qi, Weiwei
collection PubMed
description Severe aplastic anemia (SAA) is an immune-mediated bone marrow failure characterized by pancytopenia. This study was aimed at uncovering proteins of plasma that were differentially expressed in SAA patients. 8 SAA patients and 8 health controls were enrolled and detected by data independent acquisition (DIA) technology. 154 differential expression proteins (DEPs) in plasma of SAA patients were identified. GO and KEGG analyses indicated DEPs were mainly involved in the immune system process. Specifically, C-C motif chemokine 18 (CCL18), matrix metalloproteinase-3 (MMP3), histidine-rich glycoprotein (HRG), and lactotransferrin (lactoferrin (Lf)) may play an important role in the immune pathogenesis of SAA. CCL18, MMP3, HRG, and Lf might be potential biomarkers for SAA.
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spelling pubmed-91065282022-05-14 Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia Qi, Weiwei Zhang, Yu Yang, Wenhao Liu, Chunyan Wang, Huaquan Fu, Rong Shao, Zonghong Dis Markers Research Article Severe aplastic anemia (SAA) is an immune-mediated bone marrow failure characterized by pancytopenia. This study was aimed at uncovering proteins of plasma that were differentially expressed in SAA patients. 8 SAA patients and 8 health controls were enrolled and detected by data independent acquisition (DIA) technology. 154 differential expression proteins (DEPs) in plasma of SAA patients were identified. GO and KEGG analyses indicated DEPs were mainly involved in the immune system process. Specifically, C-C motif chemokine 18 (CCL18), matrix metalloproteinase-3 (MMP3), histidine-rich glycoprotein (HRG), and lactotransferrin (lactoferrin (Lf)) may play an important role in the immune pathogenesis of SAA. CCL18, MMP3, HRG, and Lf might be potential biomarkers for SAA. Hindawi 2022-05-06 /pmc/articles/PMC9106528/ /pubmed/35571618 http://dx.doi.org/10.1155/2022/3700691 Text en Copyright © 2022 Weiwei Qi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qi, Weiwei
Zhang, Yu
Yang, Wenhao
Liu, Chunyan
Wang, Huaquan
Fu, Rong
Shao, Zonghong
Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
title Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
title_full Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
title_fullStr Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
title_full_unstemmed Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
title_short Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of Severe Aplastic Anemia
title_sort abnormal proteomics profile of plasma reveals the immunological pathogenesis of severe aplastic anemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106528/
https://www.ncbi.nlm.nih.gov/pubmed/35571618
http://dx.doi.org/10.1155/2022/3700691
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