Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma

We report an initial diagnostic dilemma case of a 60-year-old male who presented with worsening hemolytic anemia, thrombocytopenia, and acute kidney injury requiring hemodialysis. His presentation was initially suspected to be secondary to thrombotic thrombocytopenic purpura (TTP) and he was treated...

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Detalles Bibliográficos
Autores principales: Oye, Melissa, Alkhasawneh, Ahmad, Quan, JR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106547/
https://www.ncbi.nlm.nih.gov/pubmed/35573505
http://dx.doi.org/10.7759/cureus.24124
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author Oye, Melissa
Alkhasawneh, Ahmad
Quan, JR
author_facet Oye, Melissa
Alkhasawneh, Ahmad
Quan, JR
author_sort Oye, Melissa
collection PubMed
description We report an initial diagnostic dilemma case of a 60-year-old male who presented with worsening hemolytic anemia, thrombocytopenia, and acute kidney injury requiring hemodialysis. His presentation was initially suspected to be secondary to thrombotic thrombocytopenic purpura (TTP) and he was treated with intravenous immunoglobulin (IVIG) and plasmapheresis. Despite treatment, he failed to improve during his admission leading to further workup revealing gamma-delta T-cell large granular lymphocytic (γδ T-LGL) leukemia. In this paper, we will discuss the features, workup, and treatment of this rare malignancy.
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spelling pubmed-91065472022-05-14 Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma Oye, Melissa Alkhasawneh, Ahmad Quan, JR Cureus Internal Medicine We report an initial diagnostic dilemma case of a 60-year-old male who presented with worsening hemolytic anemia, thrombocytopenia, and acute kidney injury requiring hemodialysis. His presentation was initially suspected to be secondary to thrombotic thrombocytopenic purpura (TTP) and he was treated with intravenous immunoglobulin (IVIG) and plasmapheresis. Despite treatment, he failed to improve during his admission leading to further workup revealing gamma-delta T-cell large granular lymphocytic (γδ T-LGL) leukemia. In this paper, we will discuss the features, workup, and treatment of this rare malignancy. Cureus 2022-04-13 /pmc/articles/PMC9106547/ /pubmed/35573505 http://dx.doi.org/10.7759/cureus.24124 Text en Copyright © 2022, Oye et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Oye, Melissa
Alkhasawneh, Ahmad
Quan, JR
Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma
title Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma
title_full Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma
title_fullStr Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma
title_full_unstemmed Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma
title_short Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma
title_sort gamma-delta large granular lymphocytic leukemia: a diagnostic dilemma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106547/
https://www.ncbi.nlm.nih.gov/pubmed/35573505
http://dx.doi.org/10.7759/cureus.24124
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