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Suppression of mutant Kirsten-RAS (KRAS(G12D))-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6

The cytoplasmic phosphatase DUSP6 and its nuclear counterpart DUSP5 are negative regulators of RAS/ERK signalling. Here we use deletion of either Dusp5 or Dusp6 to explore the roles of these phosphatases in a murine model of KRAS(G12D)-driven pancreatic cancer. By 56-days, loss of either DUSP5 or DU...

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Detalles Bibliográficos
Autores principales:	Kidger, Andrew M., Saville, Mark K., Rushworth, Linda K., Davidson, Jane, Stellzig, Julia, Ono, Motoharu, Kuebelsbeck, Ludwig A., Janssen, Klaus-Peter, Holzmann, Bernhard, Morton, Jennifer P., Sansom, Owen J., Caunt, Christopher J., Keyse, Stephen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106580/ https://www.ncbi.nlm.nih.gov/pubmed/35418690 http://dx.doi.org/10.1038/s41388-022-02302-0

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