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Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe
PURPOSE: Human milk (HM) composition is influenced by factors, like maternal diet and body stores, among other factors. For evaluating the influence of maternal fatty acid (FA) status on milk FA composition, the correlation between FA content in HM and in maternal plasma, erythrocytes, and adipose t...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106604/ https://www.ncbi.nlm.nih.gov/pubmed/35072787 http://dx.doi.org/10.1007/s00394-021-02788-6 |
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author | Giuffrida, Francesca Fleith, Mathilde Goyer, Amélie Samuel, Tinu Mary Elmelegy-Masserey, Isabelle Fontannaz, Patric Cruz-Hernandez, Cristina Thakkar, Sagar K. Monnard, Cathriona De Castro, Carlos Antonio Lavalle, Luca Rakza, Thameur Agosti, Massimo Al-Jashi, Isam Pereira, Almerinda Barroso Costeira, Maria Jose Marchini, Giovanna Vanpee, Mireille Stiris, Tom Stoicescu, Sylvia Silva, Maria Gorett Picaud, Jean-Charles Martinez-Costa, Cecilia Domellöf, Magnus Billeaud, Claude |
author_facet | Giuffrida, Francesca Fleith, Mathilde Goyer, Amélie Samuel, Tinu Mary Elmelegy-Masserey, Isabelle Fontannaz, Patric Cruz-Hernandez, Cristina Thakkar, Sagar K. Monnard, Cathriona De Castro, Carlos Antonio Lavalle, Luca Rakza, Thameur Agosti, Massimo Al-Jashi, Isam Pereira, Almerinda Barroso Costeira, Maria Jose Marchini, Giovanna Vanpee, Mireille Stiris, Tom Stoicescu, Sylvia Silva, Maria Gorett Picaud, Jean-Charles Martinez-Costa, Cecilia Domellöf, Magnus Billeaud, Claude |
author_sort | Giuffrida, Francesca |
collection | PubMed |
description | PURPOSE: Human milk (HM) composition is influenced by factors, like maternal diet and body stores, among other factors. For evaluating the influence of maternal fatty acid (FA) status on milk FA composition, the correlation between FA content in HM and in maternal plasma, erythrocytes, and adipose tissue was investigated. METHODS: 223 European women who delivered at term, provided HM samples over first four months of lactation. Venous blood and adipose tissue (only from mothers who consented and underwent a C-section delivery) were sampled at delivery. FAs were assessed in plasma, erythrocytes, adipose tissue, and HM. Evolution of HM FAs over lactation and correlations between FA content in milk and tissues and between mother’s blood and cord blood were established. RESULTS: During lactation, arachidonic acid (ARA) and docosahexaenoic acid (DHA) significantly decreased, while linoleic acid (LA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA) remained stable. Positive correlations were observed between HM and adipose tissue for palmitic, stearic, oleic, and polyunsaturated fatty acids (PUFAs). Correlations were found between milk and plasma for oleic, LA, ARA, ALA, DHA, monounsaturated fatty acids (MUFAs), and PUFAs. No correlation was observed between erythrocytes and HM FAs. LA and ALA were more concentrated in maternal blood than in infant blood, contrary to ARA and DHA, supporting that biomagnification of LCPUFAs may have occurred during pregnancy. CONCLUSIONS: These data show that maternal adipose tissue rather than erythrocytes may serve as reservoir of PUFAs and LCPUFAs for human milk. Plasma also supplies PUFAs and LCPUFAs to maternal milk. If both, adipose tissue and plasma PUFAs, are reflection of dietary intake, it is necessary to provide PUFAs and LCPUFAs during pregnancy or even before conception and lactation to ensure availability for mothers and enough supply for the infant via HM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-021-02788-6. |
format | Online Article Text |
id | pubmed-9106604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-91066042022-05-15 Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe Giuffrida, Francesca Fleith, Mathilde Goyer, Amélie Samuel, Tinu Mary Elmelegy-Masserey, Isabelle Fontannaz, Patric Cruz-Hernandez, Cristina Thakkar, Sagar K. Monnard, Cathriona De Castro, Carlos Antonio Lavalle, Luca Rakza, Thameur Agosti, Massimo Al-Jashi, Isam Pereira, Almerinda Barroso Costeira, Maria Jose Marchini, Giovanna Vanpee, Mireille Stiris, Tom Stoicescu, Sylvia Silva, Maria Gorett Picaud, Jean-Charles Martinez-Costa, Cecilia Domellöf, Magnus Billeaud, Claude Eur J Nutr Original Contribution PURPOSE: Human milk (HM) composition is influenced by factors, like maternal diet and body stores, among other factors. For evaluating the influence of maternal fatty acid (FA) status on milk FA composition, the correlation between FA content in HM and in maternal plasma, erythrocytes, and adipose tissue was investigated. METHODS: 223 European women who delivered at term, provided HM samples over first four months of lactation. Venous blood and adipose tissue (only from mothers who consented and underwent a C-section delivery) were sampled at delivery. FAs were assessed in plasma, erythrocytes, adipose tissue, and HM. Evolution of HM FAs over lactation and correlations between FA content in milk and tissues and between mother’s blood and cord blood were established. RESULTS: During lactation, arachidonic acid (ARA) and docosahexaenoic acid (DHA) significantly decreased, while linoleic acid (LA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA) remained stable. Positive correlations were observed between HM and adipose tissue for palmitic, stearic, oleic, and polyunsaturated fatty acids (PUFAs). Correlations were found between milk and plasma for oleic, LA, ARA, ALA, DHA, monounsaturated fatty acids (MUFAs), and PUFAs. No correlation was observed between erythrocytes and HM FAs. LA and ALA were more concentrated in maternal blood than in infant blood, contrary to ARA and DHA, supporting that biomagnification of LCPUFAs may have occurred during pregnancy. CONCLUSIONS: These data show that maternal adipose tissue rather than erythrocytes may serve as reservoir of PUFAs and LCPUFAs for human milk. Plasma also supplies PUFAs and LCPUFAs to maternal milk. If both, adipose tissue and plasma PUFAs, are reflection of dietary intake, it is necessary to provide PUFAs and LCPUFAs during pregnancy or even before conception and lactation to ensure availability for mothers and enough supply for the infant via HM. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-021-02788-6. Springer Berlin Heidelberg 2022-01-24 2022 /pmc/articles/PMC9106604/ /pubmed/35072787 http://dx.doi.org/10.1007/s00394-021-02788-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Contribution Giuffrida, Francesca Fleith, Mathilde Goyer, Amélie Samuel, Tinu Mary Elmelegy-Masserey, Isabelle Fontannaz, Patric Cruz-Hernandez, Cristina Thakkar, Sagar K. Monnard, Cathriona De Castro, Carlos Antonio Lavalle, Luca Rakza, Thameur Agosti, Massimo Al-Jashi, Isam Pereira, Almerinda Barroso Costeira, Maria Jose Marchini, Giovanna Vanpee, Mireille Stiris, Tom Stoicescu, Sylvia Silva, Maria Gorett Picaud, Jean-Charles Martinez-Costa, Cecilia Domellöf, Magnus Billeaud, Claude Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe |
title | Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe |
title_full | Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe |
title_fullStr | Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe |
title_full_unstemmed | Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe |
title_short | Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe |
title_sort | human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from europe |
topic | Original Contribution |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106604/ https://www.ncbi.nlm.nih.gov/pubmed/35072787 http://dx.doi.org/10.1007/s00394-021-02788-6 |
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