Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model

Atypical chemokine receptor 3 (ACKR3, formerly CXC chemokine receptor 7) is a G protein-coupled receptor that recruits β-arrestins, but is devoid of functional G protein signaling after receptor stimulation. In preclinical models of liver and lung fibrosis, ACKR3 was previously shown to be upregulat...

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Detalles Bibliográficos
Autores principales: Van Loy, Tom, De Jonghe, Steven, Castermans, Karolien, Dheedene, Wouter, Stoop, Reinout, Verschuren, Lars, Versele, Matthias, Chaltin, Patrick, Luttun, Aernout, Schols, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106635/
https://www.ncbi.nlm.nih.gov/pubmed/35562519
http://dx.doi.org/10.1007/s00018-022-04317-y

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