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A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults

PURPOSE: Dietary intake can affect energy homeostasis and influence body weight control. The aim of this study was to compare the impact of high-protein total diet replacement (HP-TDR) versus a control (CON) diet in the regulation of food intake and energy homeostasis in healthy, normal-weight adult...

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Autores principales: Oliveira, Camila L. P., Boulé, Normand G., Elliott, Sarah A., Sharma, Arya M., Siervo, Mario, Berg, Aloys, Ghosh, Sunita, Prado, Carla M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106637/
https://www.ncbi.nlm.nih.gov/pubmed/34928408
http://dx.doi.org/10.1007/s00394-021-02747-1
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author Oliveira, Camila L. P.
Boulé, Normand G.
Elliott, Sarah A.
Sharma, Arya M.
Siervo, Mario
Berg, Aloys
Ghosh, Sunita
Prado, Carla M.
author_facet Oliveira, Camila L. P.
Boulé, Normand G.
Elliott, Sarah A.
Sharma, Arya M.
Siervo, Mario
Berg, Aloys
Ghosh, Sunita
Prado, Carla M.
author_sort Oliveira, Camila L. P.
collection PubMed
description PURPOSE: Dietary intake can affect energy homeostasis and influence body weight control. The aim of this study was to compare the impact of high-protein total diet replacement (HP-TDR) versus a control (CON) diet in the regulation of food intake and energy homeostasis in healthy, normal-weight adults. METHODS: In this acute randomized controlled, cross-over study, participants completed two isocaloric arms: a) HP-TDR: 35% carbohydrate, 40% protein, and 25% fat; b) CON: 55% carbohydrate, 15% protein, and 30% fat. The diets were provided for 32 h while inside a whole-body calorimetry unit. Appetite sensations, appetite-related hormones, and energy metabolism were assessed. RESULTS: Forty-three healthy, normal-weight adults (19 females) participated. Appetite sensations did not differ between diets (all p > 0.05). Compared to the CON diet, the change in fasting blood markers during the HP-TDR intervention was smaller for peptide tyrosine-tyrosine (PYY; − 18.9 ± 7.9 pg/mL, p = 0.02) and greater for leptin (1859 ± 652 pg/mL, p = 0.007). Moreover, postprandial levels of glucagon-like peptide 1 (1.62 ± 0.36 pM, p < 0.001) and PYY (31.37 ± 8.05 pg/mL, p < 0.001) were higher in the HP-TDR. Significant correlations were observed between energy balance and satiety (r = − 0.41, p = 0.007), and energy balance and PFC (r = 0.33, p = 0.033) in the HP-TDR. CONCLUSION: Compared to the CON diet, the HP-TDR increased blood levels of anorexigenic hormones. Moreover, females and males responded differently to the intervention in terms of appetite sensations and appetite-related hormones. TRIAL REGISTRATION: NCT02811276 (retrospectively registered on 16 June 2016) and NCT03565510 (retrospectively registered on 11 June 2018).
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spelling pubmed-91066372022-05-15 A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults Oliveira, Camila L. P. Boulé, Normand G. Elliott, Sarah A. Sharma, Arya M. Siervo, Mario Berg, Aloys Ghosh, Sunita Prado, Carla M. Eur J Nutr Original Contribution PURPOSE: Dietary intake can affect energy homeostasis and influence body weight control. The aim of this study was to compare the impact of high-protein total diet replacement (HP-TDR) versus a control (CON) diet in the regulation of food intake and energy homeostasis in healthy, normal-weight adults. METHODS: In this acute randomized controlled, cross-over study, participants completed two isocaloric arms: a) HP-TDR: 35% carbohydrate, 40% protein, and 25% fat; b) CON: 55% carbohydrate, 15% protein, and 30% fat. The diets were provided for 32 h while inside a whole-body calorimetry unit. Appetite sensations, appetite-related hormones, and energy metabolism were assessed. RESULTS: Forty-three healthy, normal-weight adults (19 females) participated. Appetite sensations did not differ between diets (all p > 0.05). Compared to the CON diet, the change in fasting blood markers during the HP-TDR intervention was smaller for peptide tyrosine-tyrosine (PYY; − 18.9 ± 7.9 pg/mL, p = 0.02) and greater for leptin (1859 ± 652 pg/mL, p = 0.007). Moreover, postprandial levels of glucagon-like peptide 1 (1.62 ± 0.36 pM, p < 0.001) and PYY (31.37 ± 8.05 pg/mL, p < 0.001) were higher in the HP-TDR. Significant correlations were observed between energy balance and satiety (r = − 0.41, p = 0.007), and energy balance and PFC (r = 0.33, p = 0.033) in the HP-TDR. CONCLUSION: Compared to the CON diet, the HP-TDR increased blood levels of anorexigenic hormones. Moreover, females and males responded differently to the intervention in terms of appetite sensations and appetite-related hormones. TRIAL REGISTRATION: NCT02811276 (retrospectively registered on 16 June 2016) and NCT03565510 (retrospectively registered on 11 June 2018). Springer Berlin Heidelberg 2021-12-20 2022 /pmc/articles/PMC9106637/ /pubmed/34928408 http://dx.doi.org/10.1007/s00394-021-02747-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Contribution
Oliveira, Camila L. P.
Boulé, Normand G.
Elliott, Sarah A.
Sharma, Arya M.
Siervo, Mario
Berg, Aloys
Ghosh, Sunita
Prado, Carla M.
A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
title A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
title_full A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
title_fullStr A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
title_full_unstemmed A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
title_short A high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
title_sort high-protein total diet replacement alters the regulation of food intake and energy homeostasis in healthy, normal-weight adults
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106637/
https://www.ncbi.nlm.nih.gov/pubmed/34928408
http://dx.doi.org/10.1007/s00394-021-02747-1
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