PD-L1 – PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection

Phenotypic and transcriptional profiling of Treg cells at homeostasis reveals that TCR activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production of IL-10 and expression of the inhibitory receptor PD-1. At homeostasis, blockade of the PD-1 pathway results in en...

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Detalles Bibliográficos
Autores principales: Perry, Joseph A., Shallberg, Lindsey, Clark, Joseph T., Gullicksrud, Jodi, DeLong, Jonathan H., Douglas, Bonnie B., Hart, Andrew P., Lanzar, Zachary, O’Dea, Keenan, Konradt, Christoph, Park, Jeongho, Kuchroo, Juhi R., Grubaugh, Daniel, Zaretsky, Arielle Glatman, Brodsky, Igor E., Malefyt, Rene de Waal, Christian, David A., Sharpe, Arlene H., Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106844/
https://www.ncbi.nlm.nih.gov/pubmed/35437326
http://dx.doi.org/10.1038/s41590-022-01170-w

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