ILC1s Control Leukemia Stem Cell Fate and Limit Development of AML

Type I innate lymphoid cells (ILC1) are critical regulators of inflammation and immunity in mammalian tissues. However, their function in cancer is mostly undefined. Here we show that a high density of ILC1s induces leukemia stem cell (LSC) apoptosis in mice. At a lower density, ILC1s prevent LSCs f...

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Detalles Bibliográficos
Autores principales: Li, Zhenlong, Ma, Rui, Ma, Shoubao, Tian, Lei, Lu, Ting, Zhang, Jianying, Mundy-Bosse, Bethany L, Zhang, Bin, Marcucci, Guido, Caligiuri, Michael A., Yu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106917/
https://www.ncbi.nlm.nih.gov/pubmed/35487987
http://dx.doi.org/10.1038/s41590-022-01198-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106917/
https://www.ncbi.nlm.nih.gov/pubmed/35487987
http://dx.doi.org/10.1038/s41590-022-01198-y

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