Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes

Type 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further resear...

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Autores principales: Rajabi, Hadi, Ahmadi, Mahdi, Aslani, Somayeh, Saberianpour, Shirin, Rahbarghazi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tabriz University of Medical Sciences 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106955/
https://www.ncbi.nlm.nih.gov/pubmed/35620334
http://dx.doi.org/10.34172/apb.2022.025
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author Rajabi, Hadi
Ahmadi, Mahdi
Aslani, Somayeh
Saberianpour, Shirin
Rahbarghazi, Reza
author_facet Rajabi, Hadi
Ahmadi, Mahdi
Aslani, Somayeh
Saberianpour, Shirin
Rahbarghazi, Reza
author_sort Rajabi, Hadi
collection PubMed
description Type 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further researches have revealed an effective role of exendin-4 in treatment of T2DM related diseases. Exendin-4 is approximately similar to Glucagon-like peptide, thus it can bind to the glucagon-like peptide-1 receptor (GLP-1R) and activated different signaling pathways that are involved in various bioactivities such as apoptosis, insulin secretion and inactivation of microglial. In this review, we investigated the interesting role of exendin-4 in various kinds of T2DM related disorders through the activation of different signaling pathways.
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spelling pubmed-91069552022-05-25 Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes Rajabi, Hadi Ahmadi, Mahdi Aslani, Somayeh Saberianpour, Shirin Rahbarghazi, Reza Adv Pharm Bull Review Article Type 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further researches have revealed an effective role of exendin-4 in treatment of T2DM related diseases. Exendin-4 is approximately similar to Glucagon-like peptide, thus it can bind to the glucagon-like peptide-1 receptor (GLP-1R) and activated different signaling pathways that are involved in various bioactivities such as apoptosis, insulin secretion and inactivation of microglial. In this review, we investigated the interesting role of exendin-4 in various kinds of T2DM related disorders through the activation of different signaling pathways. Tabriz University of Medical Sciences 2022-03 2021-01-31 /pmc/articles/PMC9106955/ /pubmed/35620334 http://dx.doi.org/10.34172/apb.2022.025 Text en ©2022 The Authors. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
spellingShingle Review Article
Rajabi, Hadi
Ahmadi, Mahdi
Aslani, Somayeh
Saberianpour, Shirin
Rahbarghazi, Reza
Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
title Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
title_full Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
title_fullStr Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
title_full_unstemmed Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
title_short Exendin-4 as a Versatile Therapeutic Agent for the Amelioration of Diabetic Changes
title_sort exendin-4 as a versatile therapeutic agent for the amelioration of diabetic changes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106955/
https://www.ncbi.nlm.nih.gov/pubmed/35620334
http://dx.doi.org/10.34172/apb.2022.025
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