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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer

Breast cancer (BRCA) is one of the leading causes of death among women worldwide, and drug resistance often leads to a poor prognosis. Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between...

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Autores principales: Zhang, Xin, Zhang, Xingda, Li, Guozheng, Hao, Yi, Liu, Lei, Zhang, Lei, Chen, Yihai, Wu, Jiale, Wang, Xinheng, Yang, Shuai, Xu, Shouping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107037/
https://www.ncbi.nlm.nih.gov/pubmed/35578667
http://dx.doi.org/10.1155/2022/3143511
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author Zhang, Xin
Zhang, Xingda
Li, Guozheng
Hao, Yi
Liu, Lei
Zhang, Lei
Chen, Yihai
Wu, Jiale
Wang, Xinheng
Yang, Shuai
Xu, Shouping
author_facet Zhang, Xin
Zhang, Xingda
Li, Guozheng
Hao, Yi
Liu, Lei
Zhang, Lei
Chen, Yihai
Wu, Jiale
Wang, Xinheng
Yang, Shuai
Xu, Shouping
author_sort Zhang, Xin
collection PubMed
description Breast cancer (BRCA) is one of the leading causes of death among women worldwide, and drug resistance often leads to a poor prognosis. Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. In this study, we established a signature basis of 7 necroptosis-related lncRNAs associated with prognosis and divided BRCA patients into high- and low-risk groups. Kaplan-Meier curves all showed an adverse prognosis for patients in the high-risk group. Cox assays confirmed that risk score was an independent prognostic factor for BRCA patients. The receiver operating characteristic (ROC) curve proved the predictive accuracy of the signature and the area under the curve (AUC) values of the risk score reached 0.722. The nomogram relatively accurately predicted the prognosis of the patients. GSEA analysis suggested that the related signaling pathways and biological processes enriched in the high- and low-risk groups may influence the tumor microenvironment (TME) of BRCA. ssGSEA showed the difference in immune cell infiltration, immune pathway activation, and immune checkpoint expression between the two risk groups, with the low-risk group more suitable for immunotherapy. According to the significant difference in IC50 between risk groups, patients can be guided for an individualized treatment plan. Overall, the authors established a prognostic signature consisting of 7 necroptosis-associated lncRNAs that can independently predict the clinical outcome of BRCA patients. The difference in the tumor immune microenvironment between the low- and high-risk populations may be the reason for the resistance to immunotherapy in some patients.
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spelling pubmed-91070372022-05-15 A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer Zhang, Xin Zhang, Xingda Li, Guozheng Hao, Yi Liu, Lei Zhang, Lei Chen, Yihai Wu, Jiale Wang, Xinheng Yang, Shuai Xu, Shouping J Immunol Res Research Article Breast cancer (BRCA) is one of the leading causes of death among women worldwide, and drug resistance often leads to a poor prognosis. Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. In this study, we established a signature basis of 7 necroptosis-related lncRNAs associated with prognosis and divided BRCA patients into high- and low-risk groups. Kaplan-Meier curves all showed an adverse prognosis for patients in the high-risk group. Cox assays confirmed that risk score was an independent prognostic factor for BRCA patients. The receiver operating characteristic (ROC) curve proved the predictive accuracy of the signature and the area under the curve (AUC) values of the risk score reached 0.722. The nomogram relatively accurately predicted the prognosis of the patients. GSEA analysis suggested that the related signaling pathways and biological processes enriched in the high- and low-risk groups may influence the tumor microenvironment (TME) of BRCA. ssGSEA showed the difference in immune cell infiltration, immune pathway activation, and immune checkpoint expression between the two risk groups, with the low-risk group more suitable for immunotherapy. According to the significant difference in IC50 between risk groups, patients can be guided for an individualized treatment plan. Overall, the authors established a prognostic signature consisting of 7 necroptosis-associated lncRNAs that can independently predict the clinical outcome of BRCA patients. The difference in the tumor immune microenvironment between the low- and high-risk populations may be the reason for the resistance to immunotherapy in some patients. Hindawi 2022-05-05 /pmc/articles/PMC9107037/ /pubmed/35578667 http://dx.doi.org/10.1155/2022/3143511 Text en Copyright © 2022 Xin Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Xin
Zhang, Xingda
Li, Guozheng
Hao, Yi
Liu, Lei
Zhang, Lei
Chen, Yihai
Wu, Jiale
Wang, Xinheng
Yang, Shuai
Xu, Shouping
A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
title A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
title_full A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
title_fullStr A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
title_full_unstemmed A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
title_short A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer
title_sort novel necroptosis-associated lncrna signature can impact the immune status and predict the outcome of breast cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107037/
https://www.ncbi.nlm.nih.gov/pubmed/35578667
http://dx.doi.org/10.1155/2022/3143511
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