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Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice

Type 2 diabetes mellitus (T2DM) is a prevalent risk factor for cognitive impairment. Aerobic exercise can improve T2DM-related cognitive impairment; however, the possible mechanisms remain elusive. Thus, we assessed db/m mice and leptin receptor-deficient (db/db) mice that did or did not perform aer...

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Autores principales: Lin, Lili, Wang, Yonghua, Xu, Wenli, Huang, Chaolu, Hu, Jinrong, Chen, Xixi, Lv, Xinhuang, Qin, Yuelin, Zhao, Xiaoyong, Li, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107038/
https://www.ncbi.nlm.nih.gov/pubmed/35578689
http://dx.doi.org/10.1155/2022/6010504
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author Lin, Lili
Wang, Yonghua
Xu, Wenli
Huang, Chaolu
Hu, Jinrong
Chen, Xixi
Lv, Xinhuang
Qin, Yuelin
Zhao, Xiaoyong
Li, Haiyan
author_facet Lin, Lili
Wang, Yonghua
Xu, Wenli
Huang, Chaolu
Hu, Jinrong
Chen, Xixi
Lv, Xinhuang
Qin, Yuelin
Zhao, Xiaoyong
Li, Haiyan
author_sort Lin, Lili
collection PubMed
description Type 2 diabetes mellitus (T2DM) is a prevalent risk factor for cognitive impairment. Aerobic exercise can improve T2DM-related cognitive impairment; however, the possible mechanisms remain elusive. Thus, we assessed db/m mice and leptin receptor-deficient (db/db) mice that did or did not perform aerobic exercise (8 m/min, 60 min/day, and 5 days/week for 12 weeks). In this study, cognitive function was significantly impaired in the T2DM mice; aerobic exercise improved cognitive impairment through activating the AMPK/SIRT1 signalling pathway and inhibiting the JAK2/STAT3 signalling pathway in T2DM mice. However, after the application of RO8191 (JAK2 activator) or Compound C (AMPK inhibitor), the positive improvement of the exercise was evidently suppressed. Taken together, our data indicated that long-term aerobic exercise improves type 2 diabetes mellitus-related cognitive impairment by inhibiting JAK2/STAT3 and enhancing AMPK/SIRT1 pathways in mice.
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spelling pubmed-91070382022-05-15 Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice Lin, Lili Wang, Yonghua Xu, Wenli Huang, Chaolu Hu, Jinrong Chen, Xixi Lv, Xinhuang Qin, Yuelin Zhao, Xiaoyong Li, Haiyan Dis Markers Research Article Type 2 diabetes mellitus (T2DM) is a prevalent risk factor for cognitive impairment. Aerobic exercise can improve T2DM-related cognitive impairment; however, the possible mechanisms remain elusive. Thus, we assessed db/m mice and leptin receptor-deficient (db/db) mice that did or did not perform aerobic exercise (8 m/min, 60 min/day, and 5 days/week for 12 weeks). In this study, cognitive function was significantly impaired in the T2DM mice; aerobic exercise improved cognitive impairment through activating the AMPK/SIRT1 signalling pathway and inhibiting the JAK2/STAT3 signalling pathway in T2DM mice. However, after the application of RO8191 (JAK2 activator) or Compound C (AMPK inhibitor), the positive improvement of the exercise was evidently suppressed. Taken together, our data indicated that long-term aerobic exercise improves type 2 diabetes mellitus-related cognitive impairment by inhibiting JAK2/STAT3 and enhancing AMPK/SIRT1 pathways in mice. Hindawi 2022-05-05 /pmc/articles/PMC9107038/ /pubmed/35578689 http://dx.doi.org/10.1155/2022/6010504 Text en Copyright © 2022 Lili Lin et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Lili
Wang, Yonghua
Xu, Wenli
Huang, Chaolu
Hu, Jinrong
Chen, Xixi
Lv, Xinhuang
Qin, Yuelin
Zhao, Xiaoyong
Li, Haiyan
Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
title Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
title_full Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
title_fullStr Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
title_full_unstemmed Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
title_short Aerobic Exercise Improves Type 2 Diabetes Mellitus-Related Cognitive Impairment by Inhibiting JAK2/STAT3 and Enhancing AMPK/SIRT1 Pathways in Mice
title_sort aerobic exercise improves type 2 diabetes mellitus-related cognitive impairment by inhibiting jak2/stat3 and enhancing ampk/sirt1 pathways in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107038/
https://www.ncbi.nlm.nih.gov/pubmed/35578689
http://dx.doi.org/10.1155/2022/6010504
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