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Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients
BACKGROUND: Multiple studies have been published using a pulse oximeter's photoplethysmographic (PPG) capability to detect tissue perfusion. However, the origin of the PPG signal is still debatable. AIM: A comparative study was performed of PPG waveforms in hypertensive patients before and afte...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107079/ https://www.ncbi.nlm.nih.gov/pubmed/35239217 http://dx.doi.org/10.1111/anec.12941 |
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author | Hu, Yanchun Hu, Anming Song, Shenju |
author_facet | Hu, Yanchun Hu, Anming Song, Shenju |
author_sort | Hu, Yanchun |
collection | PubMed |
description | BACKGROUND: Multiple studies have been published using a pulse oximeter's photoplethysmographic (PPG) capability to detect tissue perfusion. However, the origin of the PPG signal is still debatable. AIM: A comparative study was performed of PPG waveforms in hypertensive patients before and after treatment with antihypertensive medication. The aim of this study was to observe the changes of PPG waveforms before and after lowering blood pressure in hypertensive patients and then to detect the relationship between blood pressure and PPG waveforms. METHODS: The PPG waveforms of 60 patients with hypertension were collected. After administration of the antihypertensive medication nitroglycerin, PPG waveforms were collected again. The changes of the T3 (time3): This phase occurred between Marker 3 and Marker 4 (this phase occurs mid‐diastolic) angle, before and after the antihypertensive medication treatment, were compared. The statistical analyses of two related groups were performed using the Paired t‐test. RESULTS: The blood perfusion waveforms of hypertensive patients before and after antihypertensive medication administration were differently indicated with the tilt angle T3. The slope angle of the T3 phase waveform increased significantly when the blood pressure dropped to normal (−41.9 ± 16.2° vs. −25.6 ± 21.9°, p < .0001), and the tilt angle of some patients was similar to that of adults with normal blood pressure. CONCLUSION: In patients with hypertension, the tilt angle of the PPG waveform in the T3 phase increased significantly after administration of the antihypertensive medication nitroglycerin. It is worth to conduct deeper research about the relationship between hypertension and the blood perfusion of microcirculation in the diastolic period. |
format | Online Article Text |
id | pubmed-9107079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91070792022-05-19 Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients Hu, Yanchun Hu, Anming Song, Shenju Ann Noninvasive Electrocardiol Original Articles BACKGROUND: Multiple studies have been published using a pulse oximeter's photoplethysmographic (PPG) capability to detect tissue perfusion. However, the origin of the PPG signal is still debatable. AIM: A comparative study was performed of PPG waveforms in hypertensive patients before and after treatment with antihypertensive medication. The aim of this study was to observe the changes of PPG waveforms before and after lowering blood pressure in hypertensive patients and then to detect the relationship between blood pressure and PPG waveforms. METHODS: The PPG waveforms of 60 patients with hypertension were collected. After administration of the antihypertensive medication nitroglycerin, PPG waveforms were collected again. The changes of the T3 (time3): This phase occurred between Marker 3 and Marker 4 (this phase occurs mid‐diastolic) angle, before and after the antihypertensive medication treatment, were compared. The statistical analyses of two related groups were performed using the Paired t‐test. RESULTS: The blood perfusion waveforms of hypertensive patients before and after antihypertensive medication administration were differently indicated with the tilt angle T3. The slope angle of the T3 phase waveform increased significantly when the blood pressure dropped to normal (−41.9 ± 16.2° vs. −25.6 ± 21.9°, p < .0001), and the tilt angle of some patients was similar to that of adults with normal blood pressure. CONCLUSION: In patients with hypertension, the tilt angle of the PPG waveform in the T3 phase increased significantly after administration of the antihypertensive medication nitroglycerin. It is worth to conduct deeper research about the relationship between hypertension and the blood perfusion of microcirculation in the diastolic period. John Wiley and Sons Inc. 2022-03-03 /pmc/articles/PMC9107079/ /pubmed/35239217 http://dx.doi.org/10.1111/anec.12941 Text en © 2022 The Authors. Annals of Noninvasive Electrocardiology pubished by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Hu, Yanchun Hu, Anming Song, Shenju Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
title | Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
title_full | Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
title_fullStr | Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
title_full_unstemmed | Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
title_short | Comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
title_sort | comparative study of photoplethysmographic waveforms with application of antihypertensive medication in hypertensive patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107079/ https://www.ncbi.nlm.nih.gov/pubmed/35239217 http://dx.doi.org/10.1111/anec.12941 |
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