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The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study

BACKGROUND: The purpose of this study was to identify changes in tear film function and meibomian gland function in children after congenital/developmental cataract surgery. METHODS: This study enrolled 16 eyes of 16 congenital/developmental cataract patients (mean age: 8.05 ± 1.43 years) who underw...

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Autores principales: Lin, Xiaolei, Li, Hongzhe, Zhou, Xiyue, Liu, Xin, Fan, Fan, Yang, Tianke, Luo, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107251/
https://www.ncbi.nlm.nih.gov/pubmed/35562718
http://dx.doi.org/10.1186/s12886-022-02446-3
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author Lin, Xiaolei
Li, Hongzhe
Zhou, Xiyue
Liu, Xin
Fan, Fan
Yang, Tianke
Luo, Yi
author_facet Lin, Xiaolei
Li, Hongzhe
Zhou, Xiyue
Liu, Xin
Fan, Fan
Yang, Tianke
Luo, Yi
author_sort Lin, Xiaolei
collection PubMed
description BACKGROUND: The purpose of this study was to identify changes in tear film function and meibomian gland function in children after congenital/developmental cataract surgery. METHODS: This study enrolled 16 eyes of 16 congenital/developmental cataract patients (mean age: 8.05 ± 1.43 years) who underwent cataract surgery and 16 eyes of 16 normal volunteers (mean age: 8.31 ± 2.18 years). Clinical assessments were conducted preoperatively and at 1 week, 1, 3 and 6 months postoperatively. Symptom questionnaires, non-invasive tear film break-up time, tear meniscus height, corneal fluorescein staining, lid margin abnormality, meibomian gland expressibility, and meibography were assessed. RESULTS: The ocular symptom score was significantly higher in congenital/developmental cataract patients compared to normal controls during the 5 visits (P = 0.009). And the average non-invasive tear film break-up time was significantly lower in congenital/developmental cataract patients compared to normal controls (P = 0.017). The first non-invasive tear film break-up time and average non-invasive tear film break-up time were lowest at 1 month postoperatively compared to baseline levels (P = 0.008 and P = 0.012, respectively). The lid margin score of the upper eyelid was significantly higher in congenital/developmental cataract patients compared to normal controls at 1 week postoperatively (P = 0.027). The meibum expressibility score decreased significantly during the 5 visits (P = 0.024). No significant difference was observed in meibomian gland tortuosity, meibomian gland width, meibomian gland area and meibomian gland length between the congenital/developmental group and normal controls preoperatively and at 6 months postoperatively (P > 0.05). CONCLUSION: Tear film stability and meibomian gland function are worsened transiently after congenital/developmental cataract surgery without accompanying meibomian gland morphological changes.
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spelling pubmed-91072512022-05-15 The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study Lin, Xiaolei Li, Hongzhe Zhou, Xiyue Liu, Xin Fan, Fan Yang, Tianke Luo, Yi BMC Ophthalmol Research BACKGROUND: The purpose of this study was to identify changes in tear film function and meibomian gland function in children after congenital/developmental cataract surgery. METHODS: This study enrolled 16 eyes of 16 congenital/developmental cataract patients (mean age: 8.05 ± 1.43 years) who underwent cataract surgery and 16 eyes of 16 normal volunteers (mean age: 8.31 ± 2.18 years). Clinical assessments were conducted preoperatively and at 1 week, 1, 3 and 6 months postoperatively. Symptom questionnaires, non-invasive tear film break-up time, tear meniscus height, corneal fluorescein staining, lid margin abnormality, meibomian gland expressibility, and meibography were assessed. RESULTS: The ocular symptom score was significantly higher in congenital/developmental cataract patients compared to normal controls during the 5 visits (P = 0.009). And the average non-invasive tear film break-up time was significantly lower in congenital/developmental cataract patients compared to normal controls (P = 0.017). The first non-invasive tear film break-up time and average non-invasive tear film break-up time were lowest at 1 month postoperatively compared to baseline levels (P = 0.008 and P = 0.012, respectively). The lid margin score of the upper eyelid was significantly higher in congenital/developmental cataract patients compared to normal controls at 1 week postoperatively (P = 0.027). The meibum expressibility score decreased significantly during the 5 visits (P = 0.024). No significant difference was observed in meibomian gland tortuosity, meibomian gland width, meibomian gland area and meibomian gland length between the congenital/developmental group and normal controls preoperatively and at 6 months postoperatively (P > 0.05). CONCLUSION: Tear film stability and meibomian gland function are worsened transiently after congenital/developmental cataract surgery without accompanying meibomian gland morphological changes. BioMed Central 2022-05-13 /pmc/articles/PMC9107251/ /pubmed/35562718 http://dx.doi.org/10.1186/s12886-022-02446-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lin, Xiaolei
Li, Hongzhe
Zhou, Xiyue
Liu, Xin
Fan, Fan
Yang, Tianke
Luo, Yi
The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
title The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
title_full The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
title_fullStr The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
title_full_unstemmed The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
title_short The influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
title_sort influence of congenital and developmental cataract surgery on the ocular surface in a six-month follow-up prospective clinical study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107251/
https://www.ncbi.nlm.nih.gov/pubmed/35562718
http://dx.doi.org/10.1186/s12886-022-02446-3
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