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Association between obesity and bone mineral density in middle-aged adults
BACKGROUND: The relationship between obesity and bone mineral density (BMD) varies in different studies. Our aim in this study was to explore the association between obesity (body mass index ≥ 30) and BMD among adults 40–59 years of age. METHODS: This study was conducted on a sample of 2218 particip...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107258/ https://www.ncbi.nlm.nih.gov/pubmed/35568921 http://dx.doi.org/10.1186/s13018-022-03161-x |
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author | Li, Yue |
author_facet | Li, Yue |
author_sort | Li, Yue |
collection | PubMed |
description | BACKGROUND: The relationship between obesity and bone mineral density (BMD) varies in different studies. Our aim in this study was to explore the association between obesity (body mass index ≥ 30) and BMD among adults 40–59 years of age. METHODS: This study was conducted on a sample of 2218 participants (986 men and 1232 women) aged 40 to 59 years from the National Health and Nutrition Examination Survey 2011–2018. The independent variable was body mass index (BMI). The outcome variable was lumbar BMD. The associations of BMI with lumbar BMD were examined using multivariable linear regression models. RESULTS: BMI was positively associated with lumbar BMD after adjusting for other covariates [β 0.006; 95% confidence interval (CI) 0.003–0.008]. An inverted U-shaped association between BMI and lumbar BMD was further identified, with the point of infection at approximately 50 kg/m(2). In the subgroup analyses, the relationship between BMI and lumbar BMD in women and blacks was an inverted U-shape. CONCLUSION: Based on the results, it may be beneficial to appropriately increase BMI to promote BMD. However, considering the inverted U-shaped association, excessive BMI may be harmful to bone health in women and blacks. |
format | Online Article Text |
id | pubmed-9107258 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91072582022-05-15 Association between obesity and bone mineral density in middle-aged adults Li, Yue J Orthop Surg Res Research Article BACKGROUND: The relationship between obesity and bone mineral density (BMD) varies in different studies. Our aim in this study was to explore the association between obesity (body mass index ≥ 30) and BMD among adults 40–59 years of age. METHODS: This study was conducted on a sample of 2218 participants (986 men and 1232 women) aged 40 to 59 years from the National Health and Nutrition Examination Survey 2011–2018. The independent variable was body mass index (BMI). The outcome variable was lumbar BMD. The associations of BMI with lumbar BMD were examined using multivariable linear regression models. RESULTS: BMI was positively associated with lumbar BMD after adjusting for other covariates [β 0.006; 95% confidence interval (CI) 0.003–0.008]. An inverted U-shaped association between BMI and lumbar BMD was further identified, with the point of infection at approximately 50 kg/m(2). In the subgroup analyses, the relationship between BMI and lumbar BMD in women and blacks was an inverted U-shape. CONCLUSION: Based on the results, it may be beneficial to appropriately increase BMI to promote BMD. However, considering the inverted U-shaped association, excessive BMI may be harmful to bone health in women and blacks. BioMed Central 2022-05-14 /pmc/articles/PMC9107258/ /pubmed/35568921 http://dx.doi.org/10.1186/s13018-022-03161-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Li, Yue Association between obesity and bone mineral density in middle-aged adults |
title | Association between obesity and bone mineral density in middle-aged adults |
title_full | Association between obesity and bone mineral density in middle-aged adults |
title_fullStr | Association between obesity and bone mineral density in middle-aged adults |
title_full_unstemmed | Association between obesity and bone mineral density in middle-aged adults |
title_short | Association between obesity and bone mineral density in middle-aged adults |
title_sort | association between obesity and bone mineral density in middle-aged adults |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107258/ https://www.ncbi.nlm.nih.gov/pubmed/35568921 http://dx.doi.org/10.1186/s13018-022-03161-x |
work_keys_str_mv | AT liyue associationbetweenobesityandbonemineraldensityinmiddleagedadults |