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SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

BACKGROUND: Cigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing redox imbalance. We previously showed that clearing mitochondrial reactive oxygen species (mtROS) protects against CS-induced pulmonary fibrosis. Howe...

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Detalles Bibliográficos
Autores principales:	Zhang, Yue, Li, Ting, Pan, Miaoxia, Wang, Wei, Huang, Wenhui, Yuan, Yafei, Xie, Zhanzhan, Chen, Yixin, Peng, Jun, Li, Xu, Meng, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107262/ https://www.ncbi.nlm.nih.gov/pubmed/35568871 http://dx.doi.org/10.1186/s12967-022-03408-5

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