Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis

In the intermediate stages of amyotrophic lateral sclerosis (ALS), surviving motor neurons (MNs) that show intrinsic resistance to TDP-43 proteinopathy can partially compensate for the loss of their more disease-susceptible counterparts. Elucidating the mechanisms of this compensation may reveal app...

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Detalles Bibliográficos
Autores principales: Hur, Seong Kwon, Hunter, Mandana, Dominique, Myrna A., Farag, Madona, Cotton-Samuel, Dejania, Khan, Tahiyana, Trojanowski, John Q., Spiller, Krista J., Lee, Virginia M.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107273/
https://www.ncbi.nlm.nih.gov/pubmed/35568882
http://dx.doi.org/10.1186/s40478-022-01373-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107273/
https://www.ncbi.nlm.nih.gov/pubmed/35568882
http://dx.doi.org/10.1186/s40478-022-01373-0

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