TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2

Dyslipidemia is considered an essential component of the pathological process of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. Although TAR DNA Binding Protein 43 kDa (TDP-43) links both familial and sporadic forms of ALS and cytoplasmic aggregates are a hallmark of most cases o...

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Detalles Bibliográficos
Autores principales: Egawa, Naohiro, Izumi, Yuishin, Suzuki, Hidefumi, Tsuge, Itaru, Fujita, Koji, Shimano, Hitoshi, Izumikawa, Keiichi, Takahashi, Nobuhiro, Tsukita, Kayoko, Enami, Takako, Nakamura, Masahiro, Watanabe, Akira, Naitoh, Motoko, Suzuki, Shigehiko, Seki, Tsuneyoshi, Kobayashi, Kazuhiro, Toda, Tatsushi, Kaji, Ryuji, Takahashi, Ryosuke, Inoue, Haruhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107471/
https://www.ncbi.nlm.nih.gov/pubmed/35568729
http://dx.doi.org/10.1038/s41598-022-12133-4

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