Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia

Hypoxia modulates senescence, but their physiological link remains unclear. Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under hypoxia. RNA-binding protein RBM38 interacted with eIF4...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Yang, He, He, Dong, Chen, Jian, Dong, Zhiqiang, Luo, Shaoxiang, Liang, Huiting, Cao, Yu, Cai, Bingcheng, Zhang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107480/
https://www.ncbi.nlm.nih.gov/pubmed/35568694
http://dx.doi.org/10.1038/s41419-022-04897-4

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