Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis

A decline in skeletal muscle mass and lower muscular strength are prognostic factors in advanced human cancers. Here, we found that breast cancer suppressed O-linked N-acetylglucosamine (O-GlcNAc) protein modification in muscle through extracellular-vesicle-encapsulated miR-122, which targets O-GlcN...

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Detalles Bibliográficos
Autores principales: Yan, Wei, Cao, Minghui, Ruan, Xianhui, Jiang, Li, Lee, Sylvia, Lemanek, Adriana, Ghassemian, Majid, Pizzo, Donald P., Wan, Yuhao, Qiao, Yueqing, Chin, Andrew R., Duggan, Erika, Wang, Dong, Nolan, John P., Esko, Jeffrey D., Schenk, Simon, Wang, Shizhen Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107513/
https://www.ncbi.nlm.nih.gov/pubmed/35469018
http://dx.doi.org/10.1038/s41556-022-00893-0

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