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Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase
Despite their low abundance, phosphoinositides play a central role in membrane traffic and signalling. PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2) are uniquely important, as they promote cell growth, survival, and migration. Pathogenic organisms have developed means to subvert phosphoinositide metabolism...
Autores principales: | Walpole, Glenn F. W., Pacheco, Jonathan, Chauhan, Neha, Clark, Jonathan, Anderson, Karen E., Abbas, Yazan M., Brabant-Kirwan, Danielle, Montaño-Rendón, Fernando, Liu, Zetao, Zhu, Hongxian, Brumell, John H., Deiters, Alexander, Stephens, Len R., Hawkins, Phillip T., Hammond, Gerald R.V., Grinstein, Sergio, Fairn, Gregory D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107517/ https://www.ncbi.nlm.nih.gov/pubmed/35484249 http://dx.doi.org/10.1038/s41556-022-00895-y |
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