Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers

BACKGROUND: Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD). By employing tandem mass tag (TMT) proteomics, thousands of proteins can be quantified simultaneously in large cohorts, making it a powerful tool for biomarke...

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Detalles Bibliográficos
Autores principales: Weiner, Sophia, Sauer, Mathias, Visser, Pieter Jelle, Tijms, Betty M., Vorontsov, Egor, Blennow, Kaj, Zetterberg, Henrik, Gobom, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107710/
https://www.ncbi.nlm.nih.gov/pubmed/35568819
http://dx.doi.org/10.1186/s12014-022-09354-0

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