Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study

The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not yet been...

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Autores principales: Si, Fenfen, Wang, Dongyan, Ji, Tianjiao, Zhang, Yong, Zhu, Shuangli, Li, Junhan, Xu, Wenbo, Tao, Zexin, Yan, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107727/
https://www.ncbi.nlm.nih.gov/pubmed/35570270
http://dx.doi.org/10.1186/s12985-022-01810-5
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author Si, Fenfen
Wang, Dongyan
Ji, Tianjiao
Zhang, Yong
Zhu, Shuangli
Li, Junhan
Xu, Wenbo
Tao, Zexin
Yan, Dongmei
author_facet Si, Fenfen
Wang, Dongyan
Ji, Tianjiao
Zhang, Yong
Zhu, Shuangli
Li, Junhan
Xu, Wenbo
Tao, Zexin
Yan, Dongmei
author_sort Si, Fenfen
collection PubMed
description The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not yet been reported in the Chinese mainland by now. Based on the AFP surveillance system of the mainland of China, this study conducted a retrospective study of AFP cases for 1985–1999: a strain of EV-A71 C1 subgenotype was found. To our knowledge, this strain (SD92-41) is the first C1 sub-genotype reported in the Chinese mainland. This study demonstrates that the C1 gene subtype also appeared in the Chinese mainland, but it is unknown whether it is an imported or a local epidemic strain. With sufficient information known from retrospective studies, the source of the SD92-41 strain will be identified and the prevalence of EV-A71 in the Chinese mainland before 1998 will be clearer.
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spelling pubmed-91077272022-05-16 Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study Si, Fenfen Wang, Dongyan Ji, Tianjiao Zhang, Yong Zhu, Shuangli Li, Junhan Xu, Wenbo Tao, Zexin Yan, Dongmei Virol J Short Report The C4 sub-genotype of Enterovirus 71 (EV71) has been identified as the most dominant sub-genotype circulating in the Chinese mainland since 1998. The circulation situation of EV71 before 1998 is not well established due to insufficient experimental data. The C1 subgenotype of EV71 has not yet been reported in the Chinese mainland by now. Based on the AFP surveillance system of the mainland of China, this study conducted a retrospective study of AFP cases for 1985–1999: a strain of EV-A71 C1 subgenotype was found. To our knowledge, this strain (SD92-41) is the first C1 sub-genotype reported in the Chinese mainland. This study demonstrates that the C1 gene subtype also appeared in the Chinese mainland, but it is unknown whether it is an imported or a local epidemic strain. With sufficient information known from retrospective studies, the source of the SD92-41 strain will be identified and the prevalence of EV-A71 in the Chinese mainland before 1998 will be clearer. BioMed Central 2022-05-15 /pmc/articles/PMC9107727/ /pubmed/35570270 http://dx.doi.org/10.1186/s12985-022-01810-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Si, Fenfen
Wang, Dongyan
Ji, Tianjiao
Zhang, Yong
Zhu, Shuangli
Li, Junhan
Xu, Wenbo
Tao, Zexin
Yan, Dongmei
Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
title Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
title_full Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
title_fullStr Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
title_full_unstemmed Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
title_short Identification of the first C1 subgenotype of enterovirus 71 in the Chinese mainland in a retrospective study
title_sort identification of the first c1 subgenotype of enterovirus 71 in the chinese mainland in a retrospective study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107727/
https://www.ncbi.nlm.nih.gov/pubmed/35570270
http://dx.doi.org/10.1186/s12985-022-01810-5
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