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Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review

Hepatitis C virus infection is a global health problem affecting >71 million people worldwide with chronic hepatitis C, 40% reproductive age group, and 8% pregnant women. Intravenous drug abuse, multi-transfusions are major risk factors in adults, while vertical transmission in pediatric populati...

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Autores principales: Rana, Ramesh, Dangal, Rajkumar, Singh, Yogendra, Gurung, Ram Bahadur, Rai, Bhim, Sharma, Amit Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the Nepal Medical Association 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107891/
https://www.ncbi.nlm.nih.gov/pubmed/35199739
http://dx.doi.org/10.31729/jnma.5501
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author Rana, Ramesh
Dangal, Rajkumar
Singh, Yogendra
Gurung, Ram Bahadur
Rai, Bhim
Sharma, Amit Kumar
author_facet Rana, Ramesh
Dangal, Rajkumar
Singh, Yogendra
Gurung, Ram Bahadur
Rai, Bhim
Sharma, Amit Kumar
author_sort Rana, Ramesh
collection PubMed
description Hepatitis C virus infection is a global health problem affecting >71 million people worldwide with chronic hepatitis C, 40% reproductive age group, and 8% pregnant women. Intravenous drug abuse, multi-transfusions are major risk factors in adults, while vertical transmission in pediatric population. It presents as a chronic liver disease, has higher risk of liver cirrhosis and even progression to hepatocellular carcinoma. Proper screening of high-risk populations including pregnancy is recommended. All diagnosed chronic hepatitis C cases should be treated with directly acting antivirals including pre-conception. This would reduce the disease burden, vertical transmission, and disability associated. However, no directly acting antivirals regimens recommendation till date due to lack of evidence on adverse fetal outcomes and are concerned about the pharmacokinetic effect regarding physiological changes during pregnancy. Therefore, in this review, we have tried to explore the possible use of directly acting antivirals regimens and their safety issues during pregnancy, and possible consideration of few pan-genotypic regimens in the late second and early third trimester. This would not only prevent vertical transmission and decrease disease burden but also help to meet the World Health Organisation 2030 target of hepatitis C virus elimination as a major public health problem.
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spelling pubmed-91078912022-05-27 Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review Rana, Ramesh Dangal, Rajkumar Singh, Yogendra Gurung, Ram Bahadur Rai, Bhim Sharma, Amit Kumar JNMA J Nepal Med Assoc Review Article Hepatitis C virus infection is a global health problem affecting >71 million people worldwide with chronic hepatitis C, 40% reproductive age group, and 8% pregnant women. Intravenous drug abuse, multi-transfusions are major risk factors in adults, while vertical transmission in pediatric population. It presents as a chronic liver disease, has higher risk of liver cirrhosis and even progression to hepatocellular carcinoma. Proper screening of high-risk populations including pregnancy is recommended. All diagnosed chronic hepatitis C cases should be treated with directly acting antivirals including pre-conception. This would reduce the disease burden, vertical transmission, and disability associated. However, no directly acting antivirals regimens recommendation till date due to lack of evidence on adverse fetal outcomes and are concerned about the pharmacokinetic effect regarding physiological changes during pregnancy. Therefore, in this review, we have tried to explore the possible use of directly acting antivirals regimens and their safety issues during pregnancy, and possible consideration of few pan-genotypic regimens in the late second and early third trimester. This would not only prevent vertical transmission and decrease disease burden but also help to meet the World Health Organisation 2030 target of hepatitis C virus elimination as a major public health problem. Journal of the Nepal Medical Association 2021-09 2021-09-30 /pmc/articles/PMC9107891/ /pubmed/35199739 http://dx.doi.org/10.31729/jnma.5501 Text en © The Author(s) 2018. https://creativecommons.org/licenses/by/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rana, Ramesh
Dangal, Rajkumar
Singh, Yogendra
Gurung, Ram Bahadur
Rai, Bhim
Sharma, Amit Kumar
Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
title Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
title_full Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
title_fullStr Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
title_full_unstemmed Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
title_short Hepatitis C Virus Infection in Pregnancy and Children: Its Implications and Treatment Considerations with Directly Acting Antivirals: A Review
title_sort hepatitis c virus infection in pregnancy and children: its implications and treatment considerations with directly acting antivirals: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107891/
https://www.ncbi.nlm.nih.gov/pubmed/35199739
http://dx.doi.org/10.31729/jnma.5501
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