Thyroid Storm in a Patient on Chronic Amiodarone Treatment

Amiodarone is a class III antiarrhythmic drug with a structure comparable to thyroid hormone and 37% iodine content by weight. In addition to direct drug cytotoxicity on thyroid cells, amiodarone deiodination in the body releases an excessive amount of iodine, which can impair thyroid function and c...

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Detalles Bibliográficos
Autores principales: Raza, Muhammad Ali, Jain, Ashish, Mumtaz, Maha, Mehmood, Talha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107913/
https://www.ncbi.nlm.nih.gov/pubmed/35586348
http://dx.doi.org/10.7759/cureus.24164
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author Raza, Muhammad Ali
Jain, Ashish
Mumtaz, Maha
Mehmood, Talha
author_facet Raza, Muhammad Ali
Jain, Ashish
Mumtaz, Maha
Mehmood, Talha
author_sort Raza, Muhammad Ali
collection PubMed
description Amiodarone is a class III antiarrhythmic drug with a structure comparable to thyroid hormone and 37% iodine content by weight. In addition to direct drug cytotoxicity on thyroid cells, amiodarone deiodination in the body releases an excessive amount of iodine, which can impair thyroid function and cause hypothyroidism or thyrotoxicosis, including thyroid storm in susceptible individuals. In this report, we discuss the case of a 52-year-old woman who experienced a thyroid storm after being treated with amiodarone, eventually leading to her death.
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spelling pubmed-91079132022-05-17 Thyroid Storm in a Patient on Chronic Amiodarone Treatment Raza, Muhammad Ali Jain, Ashish Mumtaz, Maha Mehmood, Talha Cureus Cardiology Amiodarone is a class III antiarrhythmic drug with a structure comparable to thyroid hormone and 37% iodine content by weight. In addition to direct drug cytotoxicity on thyroid cells, amiodarone deiodination in the body releases an excessive amount of iodine, which can impair thyroid function and cause hypothyroidism or thyrotoxicosis, including thyroid storm in susceptible individuals. In this report, we discuss the case of a 52-year-old woman who experienced a thyroid storm after being treated with amiodarone, eventually leading to her death. Cureus 2022-04-15 /pmc/articles/PMC9107913/ /pubmed/35586348 http://dx.doi.org/10.7759/cureus.24164 Text en Copyright © 2022, Raza et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Raza, Muhammad Ali
Jain, Ashish
Mumtaz, Maha
Mehmood, Talha
Thyroid Storm in a Patient on Chronic Amiodarone Treatment
title Thyroid Storm in a Patient on Chronic Amiodarone Treatment
title_full Thyroid Storm in a Patient on Chronic Amiodarone Treatment
title_fullStr Thyroid Storm in a Patient on Chronic Amiodarone Treatment
title_full_unstemmed Thyroid Storm in a Patient on Chronic Amiodarone Treatment
title_short Thyroid Storm in a Patient on Chronic Amiodarone Treatment
title_sort thyroid storm in a patient on chronic amiodarone treatment
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107913/
https://www.ncbi.nlm.nih.gov/pubmed/35586348
http://dx.doi.org/10.7759/cureus.24164
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AT jainashish thyroidstorminapatientonchronicamiodaronetreatment
AT mumtazmaha thyroidstorminapatientonchronicamiodaronetreatment
AT mehmoodtalha thyroidstorminapatientonchronicamiodaronetreatment

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