New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination

During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure the safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a COVID-19 messeng...

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Autores principales: Yano, Masahiro, Morioka, Tomoaki, Natsuki, Yuka, Sasaki, Keyaki, Kakutani, Yoshinori, Ochi, Akinobu, Yamazaki, Yuko, Shoji, Tetsuo, Emoto, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107966/
https://www.ncbi.nlm.nih.gov/pubmed/35135929
http://dx.doi.org/10.2169/internalmedicine.9004-21
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author Yano, Masahiro
Morioka, Tomoaki
Natsuki, Yuka
Sasaki, Keyaki
Kakutani, Yoshinori
Ochi, Akinobu
Yamazaki, Yuko
Shoji, Tetsuo
Emoto, Masanori
author_facet Yano, Masahiro
Morioka, Tomoaki
Natsuki, Yuka
Sasaki, Keyaki
Kakutani, Yoshinori
Ochi, Akinobu
Yamazaki, Yuko
Shoji, Tetsuo
Emoto, Masanori
author_sort Yano, Masahiro
collection PubMed
description During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure the safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a COVID-19 messenger ribonucleic acid (mRNA) vaccine. Laboratory tests indicated exhaustion of endogenous insulin secretion, a positive result for insulin autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous for DRB1*09:01-DQB1*03:03 haplotypes. This case suggests that COVID-19 vaccination can induce type 1 diabetes in some individuals with a genetic predisposition.
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spelling pubmed-91079662022-05-27 New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination Yano, Masahiro Morioka, Tomoaki Natsuki, Yuka Sasaki, Keyaki Kakutani, Yoshinori Ochi, Akinobu Yamazaki, Yuko Shoji, Tetsuo Emoto, Masanori Intern Med Case Report During the ongoing coronavirus disease 2019 (COVID-19) pandemic, it is critical to ensure the safety of COVID-19 vaccines. We herein report a 51-year-old Japanese woman who developed acute-onset type 1 diabetes with diabetic ketoacidosis six weeks after receiving the first dose of a COVID-19 messenger ribonucleic acid (mRNA) vaccine. Laboratory tests indicated exhaustion of endogenous insulin secretion, a positive result for insulin autoantibody, and latent thyroid autoimmunity. Human leukocyte antigen typing was homozygous for DRB1*09:01-DQB1*03:03 haplotypes. This case suggests that COVID-19 vaccination can induce type 1 diabetes in some individuals with a genetic predisposition. The Japanese Society of Internal Medicine 2022-02-08 2022-04-15 /pmc/articles/PMC9107966/ /pubmed/35135929 http://dx.doi.org/10.2169/internalmedicine.9004-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yano, Masahiro
Morioka, Tomoaki
Natsuki, Yuka
Sasaki, Keyaki
Kakutani, Yoshinori
Ochi, Akinobu
Yamazaki, Yuko
Shoji, Tetsuo
Emoto, Masanori
New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination
title New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination
title_full New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination
title_fullStr New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination
title_full_unstemmed New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination
title_short New-onset Type 1 Diabetes after COVID-19 mRNA Vaccination
title_sort new-onset type 1 diabetes after covid-19 mrna vaccination
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107966/
https://www.ncbi.nlm.nih.gov/pubmed/35135929
http://dx.doi.org/10.2169/internalmedicine.9004-21
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