Robust Effect of Hepatic Arterial Infusion Chemotherapy and Radiation Therapy on Hepatocellular Carcinoma Arising from Fontan-associated Liver Disease

Fontan-associated liver disease (FALD) caused by long-term systemic venous congestion following the Fontan procedure may eventually lead to hepatocellular carcinoma (HCC). Treatment strategies for HCC due to FALD (FALD-HCC) remain unclear. We herein report a 35-year-old man with FALD-HCC that was we...

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Detalles Bibliográficos
Autores principales: Suzuki, Hiroyuki, Niizeki, Takashi, Shirono, Tomotake, Koteda, Yusuke, Kinjyo, Yoshinao, Mizukami, Naohisa, Koda, Makoto, Ota, Satoshi, Nakano, Masahito, Okamura, Shusuke, Iwamoto, Hideki, Shimose, Shigeo, Noda, Yu, Kamachi, Naoki, Kajiwara, Akira, Suda, Kenji, Akiba, Jun, Yano, Hirohisa, Kuromatsu, Ryoko, Koga, Hironori, Torimura, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107970/
https://www.ncbi.nlm.nih.gov/pubmed/34565776
http://dx.doi.org/10.2169/internalmedicine.8154-21
Descripción
Sumario:Fontan-associated liver disease (FALD) caused by long-term systemic venous congestion following the Fontan procedure may eventually lead to hepatocellular carcinoma (HCC). Treatment strategies for HCC due to FALD (FALD-HCC) remain unclear. We herein report a 35-year-old man with FALD-HCC that was well controlled by 3 cycles of continuous infusion of 5-fluorouracil and low-dose cisplatin (low-dose FP therapy) combined with 60 Gy of radiation therapy. However, the patient ultimately died of extrahepatic metastases. A pathological autopsy revealed more than 90% necrosis in the primary HCC lesion. This case suggests that low-dose FP therapy might be effective in FALD-HCC.

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