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Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma

Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed...

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Autores principales: Imakura, Takeshi, Sato, Seidai, Tomonari, Tetsu, Murakami, Kojin, Takahashi, Naoki, Naito, Nobuhito, Mima, Masato, Kagawa, Kozo, Koyama, Kazuya, Nishimura, Haruka, Kawano, Hiroshi, Nokihara, Hiroshi, Azuma, Masahiko, Takayama, Tetsuji, Nishioka, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107987/
https://www.ncbi.nlm.nih.gov/pubmed/34544944
http://dx.doi.org/10.2169/internalmedicine.7300-21
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author Imakura, Takeshi
Sato, Seidai
Tomonari, Tetsu
Murakami, Kojin
Takahashi, Naoki
Naito, Nobuhito
Mima, Masato
Kagawa, Kozo
Koyama, Kazuya
Nishimura, Haruka
Kawano, Hiroshi
Nokihara, Hiroshi
Azuma, Masahiko
Takayama, Tetsuji
Nishioka, Yasuhiko
author_facet Imakura, Takeshi
Sato, Seidai
Tomonari, Tetsu
Murakami, Kojin
Takahashi, Naoki
Naito, Nobuhito
Mima, Masato
Kagawa, Kozo
Koyama, Kazuya
Nishimura, Haruka
Kawano, Hiroshi
Nokihara, Hiroshi
Azuma, Masahiko
Takayama, Tetsuji
Nishioka, Yasuhiko
author_sort Imakura, Takeshi
collection PubMed
description Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed tomography revealed bilateral ground-glass opacity. However, he continued to take lenvatinib for four more months until he complained of dyspnea on exertion. This is a case of lenvatinib-induced interstitial pneumonia that progressed relatively slowly with a long asymptomatic period despite the appearance of pneumonia on image findings.
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spelling pubmed-91079872022-05-27 Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma Imakura, Takeshi Sato, Seidai Tomonari, Tetsu Murakami, Kojin Takahashi, Naoki Naito, Nobuhito Mima, Masato Kagawa, Kozo Koyama, Kazuya Nishimura, Haruka Kawano, Hiroshi Nokihara, Hiroshi Azuma, Masahiko Takayama, Tetsuji Nishioka, Yasuhiko Intern Med Case Report Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed tomography revealed bilateral ground-glass opacity. However, he continued to take lenvatinib for four more months until he complained of dyspnea on exertion. This is a case of lenvatinib-induced interstitial pneumonia that progressed relatively slowly with a long asymptomatic period despite the appearance of pneumonia on image findings. The Japanese Society of Internal Medicine 2021-09-18 2022-04-15 /pmc/articles/PMC9107987/ /pubmed/34544944 http://dx.doi.org/10.2169/internalmedicine.7300-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Imakura, Takeshi
Sato, Seidai
Tomonari, Tetsu
Murakami, Kojin
Takahashi, Naoki
Naito, Nobuhito
Mima, Masato
Kagawa, Kozo
Koyama, Kazuya
Nishimura, Haruka
Kawano, Hiroshi
Nokihara, Hiroshi
Azuma, Masahiko
Takayama, Tetsuji
Nishioka, Yasuhiko
Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
title Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
title_full Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
title_fullStr Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
title_full_unstemmed Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
title_short Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
title_sort lenvatinib-induced interstitial pneumonia in a patient with hepatocellular carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107987/
https://www.ncbi.nlm.nih.gov/pubmed/34544944
http://dx.doi.org/10.2169/internalmedicine.7300-21
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