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Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma
Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107987/ https://www.ncbi.nlm.nih.gov/pubmed/34544944 http://dx.doi.org/10.2169/internalmedicine.7300-21 |
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author | Imakura, Takeshi Sato, Seidai Tomonari, Tetsu Murakami, Kojin Takahashi, Naoki Naito, Nobuhito Mima, Masato Kagawa, Kozo Koyama, Kazuya Nishimura, Haruka Kawano, Hiroshi Nokihara, Hiroshi Azuma, Masahiko Takayama, Tetsuji Nishioka, Yasuhiko |
author_facet | Imakura, Takeshi Sato, Seidai Tomonari, Tetsu Murakami, Kojin Takahashi, Naoki Naito, Nobuhito Mima, Masato Kagawa, Kozo Koyama, Kazuya Nishimura, Haruka Kawano, Hiroshi Nokihara, Hiroshi Azuma, Masahiko Takayama, Tetsuji Nishioka, Yasuhiko |
author_sort | Imakura, Takeshi |
collection | PubMed |
description | Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed tomography revealed bilateral ground-glass opacity. However, he continued to take lenvatinib for four more months until he complained of dyspnea on exertion. This is a case of lenvatinib-induced interstitial pneumonia that progressed relatively slowly with a long asymptomatic period despite the appearance of pneumonia on image findings. |
format | Online Article Text |
id | pubmed-9107987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-91079872022-05-27 Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma Imakura, Takeshi Sato, Seidai Tomonari, Tetsu Murakami, Kojin Takahashi, Naoki Naito, Nobuhito Mima, Masato Kagawa, Kozo Koyama, Kazuya Nishimura, Haruka Kawano, Hiroshi Nokihara, Hiroshi Azuma, Masahiko Takayama, Tetsuji Nishioka, Yasuhiko Intern Med Case Report Lenvatinib is a multi-targeted tyrosine kinase inhibitor available for the treatment of unresectable hepatocellular carcinoma (HCC). We herein report an 84-year-old-man with interstitial pneumonia caused by lenvatinib. Four months after the start of lenvatinib administration for HCC, chest computed tomography revealed bilateral ground-glass opacity. However, he continued to take lenvatinib for four more months until he complained of dyspnea on exertion. This is a case of lenvatinib-induced interstitial pneumonia that progressed relatively slowly with a long asymptomatic period despite the appearance of pneumonia on image findings. The Japanese Society of Internal Medicine 2021-09-18 2022-04-15 /pmc/articles/PMC9107987/ /pubmed/34544944 http://dx.doi.org/10.2169/internalmedicine.7300-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Imakura, Takeshi Sato, Seidai Tomonari, Tetsu Murakami, Kojin Takahashi, Naoki Naito, Nobuhito Mima, Masato Kagawa, Kozo Koyama, Kazuya Nishimura, Haruka Kawano, Hiroshi Nokihara, Hiroshi Azuma, Masahiko Takayama, Tetsuji Nishioka, Yasuhiko Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma |
title | Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma |
title_full | Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma |
title_fullStr | Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma |
title_full_unstemmed | Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma |
title_short | Lenvatinib-induced Interstitial Pneumonia in a Patient with Hepatocellular Carcinoma |
title_sort | lenvatinib-induced interstitial pneumonia in a patient with hepatocellular carcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107987/ https://www.ncbi.nlm.nih.gov/pubmed/34544944 http://dx.doi.org/10.2169/internalmedicine.7300-21 |
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