Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease

Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respec...

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Autores principales: Hiroshima, Yuki, Sato, Keijiro, Ueki, Toshimitsu, Sumi, Masahiko, Ueno, Mayumi, Ichikawa, Naoaki, Satomi, Hidetoshi, Kobayashi, Hikaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107996/
https://www.ncbi.nlm.nih.gov/pubmed/34565772
http://dx.doi.org/10.2169/internalmedicine.7789-21
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author Hiroshima, Yuki
Sato, Keijiro
Ueki, Toshimitsu
Sumi, Masahiko
Ueno, Mayumi
Ichikawa, Naoaki
Satomi, Hidetoshi
Kobayashi, Hikaru
author_facet Hiroshima, Yuki
Sato, Keijiro
Ueki, Toshimitsu
Sumi, Masahiko
Ueno, Mayumi
Ichikawa, Naoaki
Satomi, Hidetoshi
Kobayashi, Hikaru
author_sort Hiroshima, Yuki
collection PubMed
description Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD.
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spelling pubmed-91079962022-05-27 Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease Hiroshima, Yuki Sato, Keijiro Ueki, Toshimitsu Sumi, Masahiko Ueno, Mayumi Ichikawa, Naoaki Satomi, Hidetoshi Kobayashi, Hikaru Intern Med Case Report Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD. The Japanese Society of Internal Medicine 2021-09-25 2022-04-15 /pmc/articles/PMC9107996/ /pubmed/34565772 http://dx.doi.org/10.2169/internalmedicine.7789-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hiroshima, Yuki
Sato, Keijiro
Ueki, Toshimitsu
Sumi, Masahiko
Ueno, Mayumi
Ichikawa, Naoaki
Satomi, Hidetoshi
Kobayashi, Hikaru
Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
title Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
title_full Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
title_fullStr Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
title_full_unstemmed Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
title_short Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
title_sort rapid improvement in jaundice using transdermal isosorbide tape as a nitric oxide donor in two adult patients with transplantation-associated microangiopathy related to graft-versus-host disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107996/
https://www.ncbi.nlm.nih.gov/pubmed/34565772
http://dx.doi.org/10.2169/internalmedicine.7789-21
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