Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to its endogenous ligand CCL2, and CCR3 in the apo...

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Detalles Bibliográficos
Autores principales: Shao, Zhehua, Tan, Yangxia, Shen, Qingya, Hou, Li, Yao, Bingpeng, Qin, Jiao, Xu, Peiyu, Mao, Chunyou, Chen, Li-Nan, Zhang, Huibing, Shen, Dan-Dan, Zhang, Chao, Li, Weijie, Du, Xufei, Li, Fei, Chen, Zhi-Hua, Jiang, Yi, Xu, H. Eric, Ying, Songmin, Ma, Honglei, Zhang, Yan, Shen, Huahao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108096/
https://www.ncbi.nlm.nih.gov/pubmed/35570218
http://dx.doi.org/10.1038/s41421-022-00403-4

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