Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity

Polymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal treatment. To elucidate the mechanism and develop effective strategie...

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Detalles Bibliográficos
Autores principales: Lu, Jing, Azad, Mohammad A. K., Moreau, Julie L. M., Zhu, Yan, Jiang, Xukai, Tonta, Mary, Lam, Rachel, Wickremasinghe, Hasini, Zhao, Jinxin, Wang, Jiping, Coleman, Harold A., Formosa, Luke E., Velkov, Tony, Parkington, Helena C., Combes, Alexander N., Rosenbluh, Joseph, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108107/
https://www.ncbi.nlm.nih.gov/pubmed/35570209
http://dx.doi.org/10.1007/s00018-022-04316-z

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