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Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disea...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108150/ https://www.ncbi.nlm.nih.gov/pubmed/35586651 http://dx.doi.org/10.3389/fcvm.2022.895053 |
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author | Merlo, Andrea Carlo Troccolo, Alessandro Piredda, Elisa Porto, Italo Gil Ad, Vered |
author_facet | Merlo, Andrea Carlo Troccolo, Alessandro Piredda, Elisa Porto, Italo Gil Ad, Vered |
author_sort | Merlo, Andrea Carlo |
collection | PubMed |
description | Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disease is crucial to patient management. Myocardial infarction with obstructive coronary artery disease and MINOCA share only some risk factors and comorbid conditions. While traditional cardiovascular risk factors have a lower prevalence in MINOCA patients, atypical ones—e.g., anxiety, depression, and autoimmune diseases—are much more frequent in this population. Other conditions—e.g., pregnancy, cancer, and anti-cancer therapy—can predispose to or even induce MINOCA through various mechanisms. The evidence of such risk factors for MINOCA is still scarce and contradicting, as no randomised controlled trials exist in this field. In our work, we performed a review of registries, clinical studies, and case reports of MINOCA, in order to summarise the available data and analyse its possibile pathogenic mechanisms. |
format | Online Article Text |
id | pubmed-9108150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91081502022-05-17 Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities Merlo, Andrea Carlo Troccolo, Alessandro Piredda, Elisa Porto, Italo Gil Ad, Vered Front Cardiovasc Med Cardiovascular Medicine Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disease is crucial to patient management. Myocardial infarction with obstructive coronary artery disease and MINOCA share only some risk factors and comorbid conditions. While traditional cardiovascular risk factors have a lower prevalence in MINOCA patients, atypical ones—e.g., anxiety, depression, and autoimmune diseases—are much more frequent in this population. Other conditions—e.g., pregnancy, cancer, and anti-cancer therapy—can predispose to or even induce MINOCA through various mechanisms. The evidence of such risk factors for MINOCA is still scarce and contradicting, as no randomised controlled trials exist in this field. In our work, we performed a review of registries, clinical studies, and case reports of MINOCA, in order to summarise the available data and analyse its possibile pathogenic mechanisms. Frontiers Media S.A. 2022-05-02 /pmc/articles/PMC9108150/ /pubmed/35586651 http://dx.doi.org/10.3389/fcvm.2022.895053 Text en Copyright © 2022 Merlo, Troccolo, Piredda, Porto and Gil Ad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Merlo, Andrea Carlo Troccolo, Alessandro Piredda, Elisa Porto, Italo Gil Ad, Vered Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities |
title | Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities |
title_full | Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities |
title_fullStr | Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities |
title_full_unstemmed | Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities |
title_short | Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities |
title_sort | myocardial infarction with non-obstructive coronary arteries: risk factors and associated comorbidities |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108150/ https://www.ncbi.nlm.nih.gov/pubmed/35586651 http://dx.doi.org/10.3389/fcvm.2022.895053 |
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