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Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities

Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disea...

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Autores principales: Merlo, Andrea Carlo, Troccolo, Alessandro, Piredda, Elisa, Porto, Italo, Gil Ad, Vered
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108150/
https://www.ncbi.nlm.nih.gov/pubmed/35586651
http://dx.doi.org/10.3389/fcvm.2022.895053
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author Merlo, Andrea Carlo
Troccolo, Alessandro
Piredda, Elisa
Porto, Italo
Gil Ad, Vered
author_facet Merlo, Andrea Carlo
Troccolo, Alessandro
Piredda, Elisa
Porto, Italo
Gil Ad, Vered
author_sort Merlo, Andrea Carlo
collection PubMed
description Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disease is crucial to patient management. Myocardial infarction with obstructive coronary artery disease and MINOCA share only some risk factors and comorbid conditions. While traditional cardiovascular risk factors have a lower prevalence in MINOCA patients, atypical ones—e.g., anxiety, depression, and autoimmune diseases—are much more frequent in this population. Other conditions—e.g., pregnancy, cancer, and anti-cancer therapy—can predispose to or even induce MINOCA through various mechanisms. The evidence of such risk factors for MINOCA is still scarce and contradicting, as no randomised controlled trials exist in this field. In our work, we performed a review of registries, clinical studies, and case reports of MINOCA, in order to summarise the available data and analyse its possibile pathogenic mechanisms.
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spelling pubmed-91081502022-05-17 Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities Merlo, Andrea Carlo Troccolo, Alessandro Piredda, Elisa Porto, Italo Gil Ad, Vered Front Cardiovasc Med Cardiovascular Medicine Myocardial infarction with non-obstructive coronary arteries (MINOCA), despite a lower burden of coronary atherosclerosis, has a non-negligible prognostic impact. The label of MINOCA includes an array of different aetiologies and pathologic conditions, thus the identification of the underlying disease is crucial to patient management. Myocardial infarction with obstructive coronary artery disease and MINOCA share only some risk factors and comorbid conditions. While traditional cardiovascular risk factors have a lower prevalence in MINOCA patients, atypical ones—e.g., anxiety, depression, and autoimmune diseases—are much more frequent in this population. Other conditions—e.g., pregnancy, cancer, and anti-cancer therapy—can predispose to or even induce MINOCA through various mechanisms. The evidence of such risk factors for MINOCA is still scarce and contradicting, as no randomised controlled trials exist in this field. In our work, we performed a review of registries, clinical studies, and case reports of MINOCA, in order to summarise the available data and analyse its possibile pathogenic mechanisms. Frontiers Media S.A. 2022-05-02 /pmc/articles/PMC9108150/ /pubmed/35586651 http://dx.doi.org/10.3389/fcvm.2022.895053 Text en Copyright © 2022 Merlo, Troccolo, Piredda, Porto and Gil Ad. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Merlo, Andrea Carlo
Troccolo, Alessandro
Piredda, Elisa
Porto, Italo
Gil Ad, Vered
Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
title Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
title_full Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
title_fullStr Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
title_full_unstemmed Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
title_short Myocardial Infarction With Non-obstructive Coronary Arteries: Risk Factors and Associated Comorbidities
title_sort myocardial infarction with non-obstructive coronary arteries: risk factors and associated comorbidities
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108150/
https://www.ncbi.nlm.nih.gov/pubmed/35586651
http://dx.doi.org/10.3389/fcvm.2022.895053
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