Cargando…

Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer’s Disease—A Longitudinal Study

Aging is the main risk factor for sporadic Alzheimer’s disease (AD), which is characterized by the cerebral deposition of β-amyloid peptides (Aβ) and cognitive decline. Mitochondrial dysfunction is also characteristic of the disease and represents a hallmark of both, aging and neurodegeneration. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reutzel, Martina, Grewal, Rekha, Joppe, Aljoscha, Eckert, Gunter P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108248/ https://www.ncbi.nlm.nih.gov/pubmed/35585868 http://dx.doi.org/10.3389/fnagi.2022.875989

Ejemplares similares

Cerebral Mitochondrial Function and Cognitive Performance during Aging: A Longitudinal Study in NMRI Mice
por: Reutzel, Martina, et al.
Publicado: (2020)

MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer’s disease
por: Pohland, Maximilian, et al.
Publicado: (2018)

Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice
por: Reutzel, Martina, et al.
Publicado: (2018)

Impact of Silibinin A on Bioenergetics in PC12APP(sw) Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria
por: Esselun, Carsten, et al.
Publicado: (2021)

Hesperetin Nanocrystals Improve Mitochondrial Function in a Cell Model of Early Alzheimer Disease
por: Babylon, Lukas, et al.
Publicado: (2021)

The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study
por: Ismail, Rola, et al.
Publicado: (2020)

Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer’s Disease
por: Baek, Min Seok, et al.
Publicado: (2022)

Vestibular Function and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging
por: Kamil, Rebecca J., et al.
Publicado: (2018)

Sensory Impairment and Beta-Amyloid Deposition in the Baltimore Longitudinal Study of Aging
por: Armstrong, Nicole, et al.
Publicado: (2021)

Sensory impairment and beta‐amyloid deposition in the Baltimore longitudinal study of aging
por: Yesantharao, Lekha, et al.
Publicado: (2023)

Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline
por: Mehta, Neel H., et al.
Publicado: (2023)

Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice
por: Hosokawa, Masato, et al.
Publicado: (2017)

Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease risk
por: Salih, Dervis A, et al.
Publicado: (2019)

Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer’s disease
por: Stahr, Pascal-L., et al.
Publicado: (2021)

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
por: Krabbe, Grietje, et al.
Publicado: (2013)

Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
por: Vacher, Michael, et al.
Publicado: (2019)

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease
por: Melzer, Tracy R., et al.
Publicado: (2019)

Cognitive improvements and reduction in amyloid plaque deposition by saikosaponin D treatment in a murine model of Alzheimer's disease
por: Zhou, Li, et al.
Publicado: (2020)

Differential Effects of Silibinin A on Mitochondrial Function in Neuronal PC12 and HepG2 Liver Cells
por: Esselun, Carsten, et al.
Publicado: (2019)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
por: Price, Brittani R., et al.
Publicado: (2020)

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients
por: Dinkel, Felix, et al.
Publicado: (2020)

Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits
por: Xu, Guilian, et al.
Publicado: (2015)

Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer’s disease
por: Gupta, Deepak Prasad, et al.
Publicado: (2023)

Amyloid-Beta Interaction with Mitochondria
por: Pagani, Lucia, et al.
Publicado: (2011)

HEARING IMPAIRMENT, COGNITIVE PERFORMANCE, AND BETA-AMYLOID DEPOSITION IN THE ARIC-PET AMYLOID IMAGING STUDY
por: Deal, Jennifer A, et al.
Publicado: (2019)

Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition
por: Risacher, Shannon L., et al.
Publicado: (2019)

Early Life Obesity Increases Neuroinflammation, Amyloid Beta Deposition, and Cognitive Decline in a Mouse Model of Alzheimer’s Disease
por: So, Simon W., et al.
Publicado: (2023)

Longitudinal assessment of amyloid-beta deposition in initially amyloid-negative non-demented individuals with [11C]-PIB PET imaging
por: Hatashita, Shizuo, et al.
Publicado: (2021)

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
por: Marr, Robert A., et al.
Publicado: (2014)

Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer’s disease pathogenesis
por: Li, Nuo-Min, et al.
Publicado: (2019)

Serum albumin and beta-amyloid deposition in the human brain
por: Kim, Jee Wook, et al.
Publicado: (2020)

Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina
por: Barton, Shawn M., et al.
Publicado: (2021)

Amyloid Beta in Aging and Alzheimer’s Disease
por: Sehar, Ujala, et al.
Publicado: (2022)

Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
por: Kim, Chan‐Mi, et al.
Publicado: (2021)

Serum metabolites associated with brain amyloid beta deposition, cognition and dementia progression
por: Nho, Kwangsik, et al.
Publicado: (2021)

Amyloid-beta Alzheimer targets — protein processing, lipid rafts, and amyloid-beta pores
por: Arbor, Sage C., et al.
Publicado: (2016)

Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer’s Disease Progression
por: Findley, Caleigh A., et al.
Publicado: (2019)

Familial Alzheimer’s Disease-Related Mutations Differentially Alter Stability of Amyloid-Beta Aggregates
por: Rezaei-Ghaleh, Nasrollah, et al.
Publicado: (2023)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Mitochondrial Phospholipid Homeostasis Is Regulated by the i-AAA Protease PaIAP and Affects Organismic Aging
por: Löser, Timo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7if0hi1lo08h6ihi86tihbq5a4