Furin and TMPRSS2 Resistant Spike Induces Robust Humoral and Cellular Immunity Against SARS-CoV-2 Lethal Infection

An effective COVID-19 vaccine against broad SARS-CoV-2 variants is still an unmet need. In the study, the vesicular stomatitis virus (VSV)-based vector was used to express the SARS-CoV-2 Spike protein to identify better vaccine designs. The replication-competent of the recombinant VSV-spike virus wi...

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Detalles Bibliográficos
Autores principales: Lin, Jhe-Jhih, Tien, Chih-Feng, Kuo, Yi-Ping, Lin, En-Ju, Tsai, Wei-Hsiang, Chen, Ming-Yu, Tsai, Pei-Ju, Su, Yu-Wen, Pathak, Nikhil, Yang, Jinn-Moon, Yu, Chia-Yi, Chuang, Zih-Shiuan, Wu, Han-Chieh, Tsai, Wan-Ting, Dai, Shih-Syong, Liao, Hung-Chun, Chai, Kit Man, Su, Yu-Siang, Chuang, Tsung-Hsien, Liu, Shih-Jen, Chen, Hsin-Wei, Dou, Horng-Yunn, Chen, Feng-Jui, Chen, Chiung-Tong, Liao, Chin-Len, Yu, Guann-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108258/
https://www.ncbi.nlm.nih.gov/pubmed/35585971
http://dx.doi.org/10.3389/fimmu.2022.872047

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