A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer’s and Parkinson’s diseases, cerebral ischemia reperfusion injury, c...

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Autores principales: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Jamal, Hazha Hadayat, Taheri, Mohammad, Hajiesmaeili, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108330/
https://www.ncbi.nlm.nih.gov/pubmed/35586497
http://dx.doi.org/10.3389/fonc.2022.870996
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author Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Jamal, Hazha Hadayat
Taheri, Mohammad
Hajiesmaeili, Mohammadreza
author_facet Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Jamal, Hazha Hadayat
Taheri, Mohammad
Hajiesmaeili, Mohammadreza
author_sort Ghafouri-Fard, Soudeh
collection PubMed
description miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer’s and Parkinson’s diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.
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spelling pubmed-91083302022-05-17 A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders Ghafouri-Fard, Soudeh Khoshbakht, Tayyebeh Hussen, Bashdar Mahmud Jamal, Hazha Hadayat Taheri, Mohammad Hajiesmaeili, Mohammadreza Front Oncol Oncology miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer’s and Parkinson’s diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions. Frontiers Media S.A. 2022-05-02 /pmc/articles/PMC9108330/ /pubmed/35586497 http://dx.doi.org/10.3389/fonc.2022.870996 Text en Copyright © 2022 Ghafouri-Fard, Khoshbakht, Hussen, Jamal, Taheri and Hajiesmaeili https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ghafouri-Fard, Soudeh
Khoshbakht, Tayyebeh
Hussen, Bashdar Mahmud
Jamal, Hazha Hadayat
Taheri, Mohammad
Hajiesmaeili, Mohammadreza
A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
title A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
title_full A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
title_fullStr A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
title_full_unstemmed A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
title_short A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders
title_sort comprehensive review on function of mir-15b-5p in malignant and non-malignant disorders
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108330/
https://www.ncbi.nlm.nih.gov/pubmed/35586497
http://dx.doi.org/10.3389/fonc.2022.870996
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