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Potential Strategies for Kidney Regeneration With Stem Cells: An Overview

Kidney diseases are a major health problem worldwide. Despite advances in drug therapies, they are only capable of slowing the progression of kidney diseases. Accordingly, potential kidney regeneration strategies with stem cells have begun to be explored. There are two different directions for regen...

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Detalles Bibliográficos
Autores principales: Tsuji, Kenji, Kitamura, Shinji, Wada, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108336/
https://www.ncbi.nlm.nih.gov/pubmed/35586342
http://dx.doi.org/10.3389/fcell.2022.892356
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author Tsuji, Kenji
Kitamura, Shinji
Wada, Jun
author_facet Tsuji, Kenji
Kitamura, Shinji
Wada, Jun
author_sort Tsuji, Kenji
collection PubMed
description Kidney diseases are a major health problem worldwide. Despite advances in drug therapies, they are only capable of slowing the progression of kidney diseases. Accordingly, potential kidney regeneration strategies with stem cells have begun to be explored. There are two different directions for regenerative strategies, de novo whole kidney fabrication with stem cells, and stem cell therapy. De novo whole kidney strategies include: 1) decellularized scaffold technology, 2) 3D bioprinting based on engineering technology, 3) kidney organoid fabrication, 4) blastocyst complementation with chimeric technology, and 5) the organogenic niche method. Meanwhile, stem cell therapy strategies include 1) injection of stem cells, including mesenchymal stem cells, nephron progenitor cells, adult kidney stem cells and multi-lineage differentiating stress enduring cells, and 2) injection of protective factors secreted from these stem cells, including growth factors, chemokines, and extracellular vesicles containing microRNAs, mRNAs and proteins. Over the past few decades, there have been remarkable step-by-step developments in these strategies. Here, we review the current advances in the potential strategies for kidney regeneration using stem cells, along with their challenges for possible clinical use in the future.
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spelling pubmed-91083362022-05-17 Potential Strategies for Kidney Regeneration With Stem Cells: An Overview Tsuji, Kenji Kitamura, Shinji Wada, Jun Front Cell Dev Biol Cell and Developmental Biology Kidney diseases are a major health problem worldwide. Despite advances in drug therapies, they are only capable of slowing the progression of kidney diseases. Accordingly, potential kidney regeneration strategies with stem cells have begun to be explored. There are two different directions for regenerative strategies, de novo whole kidney fabrication with stem cells, and stem cell therapy. De novo whole kidney strategies include: 1) decellularized scaffold technology, 2) 3D bioprinting based on engineering technology, 3) kidney organoid fabrication, 4) blastocyst complementation with chimeric technology, and 5) the organogenic niche method. Meanwhile, stem cell therapy strategies include 1) injection of stem cells, including mesenchymal stem cells, nephron progenitor cells, adult kidney stem cells and multi-lineage differentiating stress enduring cells, and 2) injection of protective factors secreted from these stem cells, including growth factors, chemokines, and extracellular vesicles containing microRNAs, mRNAs and proteins. Over the past few decades, there have been remarkable step-by-step developments in these strategies. Here, we review the current advances in the potential strategies for kidney regeneration using stem cells, along with their challenges for possible clinical use in the future. Frontiers Media S.A. 2022-05-02 /pmc/articles/PMC9108336/ /pubmed/35586342 http://dx.doi.org/10.3389/fcell.2022.892356 Text en Copyright © 2022 Tsuji, Kitamura and Wada. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Tsuji, Kenji
Kitamura, Shinji
Wada, Jun
Potential Strategies for Kidney Regeneration With Stem Cells: An Overview
title Potential Strategies for Kidney Regeneration With Stem Cells: An Overview
title_full Potential Strategies for Kidney Regeneration With Stem Cells: An Overview
title_fullStr Potential Strategies for Kidney Regeneration With Stem Cells: An Overview
title_full_unstemmed Potential Strategies for Kidney Regeneration With Stem Cells: An Overview
title_short Potential Strategies for Kidney Regeneration With Stem Cells: An Overview
title_sort potential strategies for kidney regeneration with stem cells: an overview
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108336/
https://www.ncbi.nlm.nih.gov/pubmed/35586342
http://dx.doi.org/10.3389/fcell.2022.892356
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