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Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas

Gastric cancer is the second most common cancer in Japan. The incidence of gastric cancer remains high owing to the increase in the elderly population. Endoscopy outperforms radiography in identifying early gastric cancer (EGC). Furthermore, image-enhanced endoscopy (IEE) has been developed and impl...

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Autores principales: Kurumi, Hiroki, Sakaguchi, Takuki, Hashiguchi, Keiichi, Yamashita, Taro, Fujii, Masashi, Ikebuchi, Yuichiro, Yoshida, Akira, Isomoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108360/
https://www.ncbi.nlm.nih.gov/pubmed/35586493
http://dx.doi.org/10.3389/fonc.2022.861868
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author Kurumi, Hiroki
Sakaguchi, Takuki
Hashiguchi, Keiichi
Yamashita, Taro
Fujii, Masashi
Ikebuchi, Yuichiro
Yoshida, Akira
Isomoto, Hajime
author_facet Kurumi, Hiroki
Sakaguchi, Takuki
Hashiguchi, Keiichi
Yamashita, Taro
Fujii, Masashi
Ikebuchi, Yuichiro
Yoshida, Akira
Isomoto, Hajime
author_sort Kurumi, Hiroki
collection PubMed
description Gastric cancer is the second most common cancer in Japan. The incidence of gastric cancer remains high owing to the increase in the elderly population. Endoscopy outperforms radiography in identifying early gastric cancer (EGC). Furthermore, image-enhanced endoscopy (IEE) has been developed and implemented worldwide in clinical practice. Magnifying IEE images can help to visualize the microvascular pattern and microstructure architecture, which is used for the characterization of EGC. However, accurate endoscopic diagnosis requires the experience and skill of endoscopists, making an objective and simple diagnostic method desirable. In this retrospective study, we investigated the diagnostic yield of 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) for identifying gastric cancers and high-grade adenomas. In total, 52 lesions from 43 patients were ultimately included in the study. We detected 5-ALA-mediated protoporphyrin IX fluorescence in 45 of the 52 lesions that were initially intended for PDD, resulting in a detection rate of 86.5%, whereas each signet ring cell carcinoma was negative using 5-ALA PDD. In eight of the patients with multiple lesions, 17 lesions were identified using 5-ALA PDD. Again, we took biopsies from six areas that we suspected as new lesions. While 4 lesions were gastric neoplasms resected by endoscopic submucosal dissection, two other lesions were normal. Preoperative 5-ALA-PDD could provide additional diagnostic yields to detect such multiple lesions simultaneously. No severe adverse events were observed. Prospective multicenter studies are warranted to confirm the usefulness of 5-ALA PDD for EGC identification.
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spelling pubmed-91083602022-05-17 Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas Kurumi, Hiroki Sakaguchi, Takuki Hashiguchi, Keiichi Yamashita, Taro Fujii, Masashi Ikebuchi, Yuichiro Yoshida, Akira Isomoto, Hajime Front Oncol Oncology Gastric cancer is the second most common cancer in Japan. The incidence of gastric cancer remains high owing to the increase in the elderly population. Endoscopy outperforms radiography in identifying early gastric cancer (EGC). Furthermore, image-enhanced endoscopy (IEE) has been developed and implemented worldwide in clinical practice. Magnifying IEE images can help to visualize the microvascular pattern and microstructure architecture, which is used for the characterization of EGC. However, accurate endoscopic diagnosis requires the experience and skill of endoscopists, making an objective and simple diagnostic method desirable. In this retrospective study, we investigated the diagnostic yield of 5-aminolevulinic acid (5-ALA)-mediated photodynamic diagnosis (PDD) for identifying gastric cancers and high-grade adenomas. In total, 52 lesions from 43 patients were ultimately included in the study. We detected 5-ALA-mediated protoporphyrin IX fluorescence in 45 of the 52 lesions that were initially intended for PDD, resulting in a detection rate of 86.5%, whereas each signet ring cell carcinoma was negative using 5-ALA PDD. In eight of the patients with multiple lesions, 17 lesions were identified using 5-ALA PDD. Again, we took biopsies from six areas that we suspected as new lesions. While 4 lesions were gastric neoplasms resected by endoscopic submucosal dissection, two other lesions were normal. Preoperative 5-ALA-PDD could provide additional diagnostic yields to detect such multiple lesions simultaneously. No severe adverse events were observed. Prospective multicenter studies are warranted to confirm the usefulness of 5-ALA PDD for EGC identification. Frontiers Media S.A. 2022-05-02 /pmc/articles/PMC9108360/ /pubmed/35586493 http://dx.doi.org/10.3389/fonc.2022.861868 Text en Copyright © 2022 Kurumi, Sakaguchi, Hashiguchi, Yamashita, Fujii, Ikebuchi, Yoshida and Isomoto https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kurumi, Hiroki
Sakaguchi, Takuki
Hashiguchi, Keiichi
Yamashita, Taro
Fujii, Masashi
Ikebuchi, Yuichiro
Yoshida, Akira
Isomoto, Hajime
Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas
title Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas
title_full Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas
title_fullStr Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas
title_full_unstemmed Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas
title_short Photodynamic Diagnosis for the Identification of Intestinal-Type Gastric Cancers and High-Grade Adenomas
title_sort photodynamic diagnosis for the identification of intestinal-type gastric cancers and high-grade adenomas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108360/
https://www.ncbi.nlm.nih.gov/pubmed/35586493
http://dx.doi.org/10.3389/fonc.2022.861868
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