Safety and immunogenicity of Nanocovax, a SARS-CoV-2 recombinant spike protein vaccine: Interim results of a double-blind, randomised controlled phase 1 and 2 trial

BACKGROUND: Nanocovax is a recombinant severe acute respiratory syndrome coronavirus 2 subunit vaccine composed of full-length prefusion stabilized recombinant SARS-CoV-2 spike glycoproteins (S-2P) and aluminium hydroxide adjuvant. METHODS: We conducted a dose-escalation, open label trial (phase 1)...

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Detalles Bibliográficos
Autores principales: Nguyen, Thuy P., Do, Quyet, Phan, Lan T., Dinh, Duc V., Khong, Hiep, Hoang, Luong V., Nguyen, Thuong V., Pham, Hung N., Chu, Men V., Nguyen, Toan T., Pham, Quang D., Le, Tri M., Trang, Tuyen N.T., Dinh, Thanh T., Vo, Thuong V., Vu, Thao T., Nguyen, Quynh B.P., Phan, Vuong T., Nguyen, Luong V., Nguyen, Giang T., Tran, Phong M., Nghiem, Thuan D., Tran, Tien V., Nguyen, Tien G., Tran, Tuynh Q., Nguyen, Linh T., Do, Anh T., Nguyen, Dung D., Ho, Son A., Nguyen, Viet T., Pham, Dung T., Tran, Hieu B., Vu, Son T., Hoang, Su X., Do, Trung M., Nguyen, Xuan T., Le, Giang Q., Tran, Ton, Cao, Thang M., Dao, Huy M., Nguyen, Thao T.T., Doan, Uyen Y, Le, Vy T.T., Tran, Linh P., Nguyen, Ngoc M., Nguyen, Ngoc T., Pham, Hang T.T., Nguyen, Quan H., Nguyen, Hieu T., Nguyen, Hang L.K., Tran, Vinh T., Tran, Mai T.N., Nguyen, Truc T.T., Ha, Phat T., Huynh, Hieu T., Nguyen, Khanh D., Thuan, Ung T., Doan, Chung C., Do, Si M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108376/
https://www.ncbi.nlm.nih.gov/pubmed/35602004
http://dx.doi.org/10.1016/j.lanwpc.2022.100474

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