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Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma

BACKGROUND AND PURPOSE: This study was conducted to explore the plasma drug concentration of propranolol in Chinese Han patients with infantile haemangioma (IH) and the influencing factors, as well as the relationship among plasma drug concentrations of propranolol, β1-AR mutation and CYP2D6 188C>...

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Autores principales: Li, Li, Yu, Lu, He, Huan, Wei, Li, Xu, Zigang, Zhao, Libo, Sun, Yujuan, Zhang, Bin, Liu, Yuanxiang, He, Rui, Wang, Xiaoling, Ma, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108385/
https://www.ncbi.nlm.nih.gov/pubmed/35586822
http://dx.doi.org/10.3389/fped.2022.849496
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author Li, Li
Yu, Lu
He, Huan
Wei, Li
Xu, Zigang
Zhao, Libo
Sun, Yujuan
Zhang, Bin
Liu, Yuanxiang
He, Rui
Wang, Xiaoling
Ma, Lin
author_facet Li, Li
Yu, Lu
He, Huan
Wei, Li
Xu, Zigang
Zhao, Libo
Sun, Yujuan
Zhang, Bin
Liu, Yuanxiang
He, Rui
Wang, Xiaoling
Ma, Lin
author_sort Li, Li
collection PubMed
description BACKGROUND AND PURPOSE: This study was conducted to explore the plasma drug concentration of propranolol in Chinese Han patients with infantile haemangioma (IH) and the influencing factors, as well as the relationship among plasma drug concentrations of propranolol, β1-AR mutation and CYP2D6 188C>T, efficacy, and safety. EXPERIMENTAL APPROACH: From January 2018 to April 2019, 140 patients with IH who were admitted to the hospital for oral propranolol and agreed to have their plasma concentration of propranolol tested, including 112 patients with β1-AR and CYP2D6 gene tested. KEY RESULTS AND CONCLUSIONS AND IMPLICATIONS: The mean peak blood levels of propranolol, 4-hydroxypropranolol (4-OH-P), and N-deisopropylpropranolol (NDP) were 60.35 ± 37.90, 1.90 ± 2.37, and 0.24 ± 0.18 ng/ml, respectively. The mean trough blood levels of propranolol, 4-OH-P, and NDP were 24.98 ± 17.68, 0.45 ± 0.52, and 0.05±0.05 ng/ml, respectively. The higher the dose of propranolol, the higher the plasma concentration of propranolol (p = 0.031). The plasma concentration of propranolol was not related to the treatment efficacy.
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spelling pubmed-91083852022-05-17 Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma Li, Li Yu, Lu He, Huan Wei, Li Xu, Zigang Zhao, Libo Sun, Yujuan Zhang, Bin Liu, Yuanxiang He, Rui Wang, Xiaoling Ma, Lin Front Pediatr Pediatrics BACKGROUND AND PURPOSE: This study was conducted to explore the plasma drug concentration of propranolol in Chinese Han patients with infantile haemangioma (IH) and the influencing factors, as well as the relationship among plasma drug concentrations of propranolol, β1-AR mutation and CYP2D6 188C>T, efficacy, and safety. EXPERIMENTAL APPROACH: From January 2018 to April 2019, 140 patients with IH who were admitted to the hospital for oral propranolol and agreed to have their plasma concentration of propranolol tested, including 112 patients with β1-AR and CYP2D6 gene tested. KEY RESULTS AND CONCLUSIONS AND IMPLICATIONS: The mean peak blood levels of propranolol, 4-hydroxypropranolol (4-OH-P), and N-deisopropylpropranolol (NDP) were 60.35 ± 37.90, 1.90 ± 2.37, and 0.24 ± 0.18 ng/ml, respectively. The mean trough blood levels of propranolol, 4-OH-P, and NDP were 24.98 ± 17.68, 0.45 ± 0.52, and 0.05±0.05 ng/ml, respectively. The higher the dose of propranolol, the higher the plasma concentration of propranolol (p = 0.031). The plasma concentration of propranolol was not related to the treatment efficacy. Frontiers Media S.A. 2022-05-02 /pmc/articles/PMC9108385/ /pubmed/35586822 http://dx.doi.org/10.3389/fped.2022.849496 Text en Copyright © 2022 Li, Yu, He, Wei, Xu, Zhao, Sun, Zhang, Liu, He, Wang and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Li, Li
Yu, Lu
He, Huan
Wei, Li
Xu, Zigang
Zhao, Libo
Sun, Yujuan
Zhang, Bin
Liu, Yuanxiang
He, Rui
Wang, Xiaoling
Ma, Lin
Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma
title Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma
title_full Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma
title_fullStr Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma
title_full_unstemmed Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma
title_short Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma
title_sort plasma drug concentration of propranolol and genetic study in chinese han patients with infantile haemangioma
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108385/
https://www.ncbi.nlm.nih.gov/pubmed/35586822
http://dx.doi.org/10.3389/fped.2022.849496
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