The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers

Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. Here we review GFRα biological functions and discussed the evidence indicating whether GFR...

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Detalles Bibliográficos
Autores principales: Li, Qingshang, Cao, Zhijun, Zhao, Shuliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108399/
https://www.ncbi.nlm.nih.gov/pubmed/35582425
http://dx.doi.org/10.7150/ijms.64133
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author Li, Qingshang
Cao, Zhijun
Zhao, Shuliang
author_facet Li, Qingshang
Cao, Zhijun
Zhao, Shuliang
author_sort Li, Qingshang
collection PubMed
description Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. Here we review GFRα biological functions and discussed the evidence indicating whether GFRα signaling complex present novel opportunities for oncogenic intervention and treatment resistance. Thus, our work systematically reviewed the emerging role of GFRα family members in cancers, and provided novel insights for further researches.
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spelling pubmed-91083992022-05-16 The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers Li, Qingshang Cao, Zhijun Zhao, Shuliang Int J Med Sci Review Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. Here we review GFRα biological functions and discussed the evidence indicating whether GFRα signaling complex present novel opportunities for oncogenic intervention and treatment resistance. Thus, our work systematically reviewed the emerging role of GFRα family members in cancers, and provided novel insights for further researches. Ivyspring International Publisher 2022-03-28 /pmc/articles/PMC9108399/ /pubmed/35582425 http://dx.doi.org/10.7150/ijms.64133 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Li, Qingshang
Cao, Zhijun
Zhao, Shuliang
The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
title The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
title_full The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
title_fullStr The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
title_full_unstemmed The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
title_short The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
title_sort emerging portrait of glial cell line-derived neurotrophic factor family receptor alpha (gfrα) in cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108399/
https://www.ncbi.nlm.nih.gov/pubmed/35582425
http://dx.doi.org/10.7150/ijms.64133
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