Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

AMP-activated protein kinase (AMPK) coordinates energy homeostasis during metabolic and energy stress. We report that the catalytic subunit isoform AMPK-α1 (but not α2) is cleaved by caspase-3 at an early stage during induction of apoptosis. AMPK-α1 cleavage occurs following Asp529, generating an ∼5...

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Detalles Bibliográficos
Autores principales: Cheratta, Anees Rahman, Thayyullathil, Faisal, Hawley, Simon A., Ross, Fiona A., Atrih, Abdelmajdid, Lamont, Douglas J., Pallichankandy, Siraj, Subburayan, Karthikeyan, Alakkal, Ameer, Rezgui, Rachid, Gray, Alex, Hardie, D. Grahame, Galadari, Sehamuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108549/
https://www.ncbi.nlm.nih.gov/pubmed/35508122
http://dx.doi.org/10.1016/j.celrep.2022.110761

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