Cholesterol determines the cytosolic entry and seeded aggregation of tau

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner. To accomplish this, tau must cross cell-limiting membranes, a process that is poorly understood. Here, we establish assays for the study of tau entry into the cytosol as a phenomenon distinct from uptake, in r...

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Detalles Bibliográficos
Autores principales: Tuck, Benjamin J., Miller, Lauren V.C., Katsinelos, Taxiarchis, Smith, Annabel E., Wilson, Emma L., Keeling, Sophie, Cheng, Shi, Vaysburd, Marina J., Knox, Claire, Tredgett, Lucy, Metzakopian, Emmanouil, James, Leo C., McEwan, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108550/
https://www.ncbi.nlm.nih.gov/pubmed/35508140
http://dx.doi.org/10.1016/j.celrep.2022.110776

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