Cargando…
A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing
Pathogenic bacteria infection is a serious threat to human public health due to the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option to improve the efficiency compared to conventional therapeutic agents. In addition to the drug loadin...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108595/ https://www.ncbi.nlm.nih.gov/pubmed/35274475 http://dx.doi.org/10.1002/advs.202105223 |
_version_ | 1784708740511956992 |
---|---|
author | He, Xiaojun Dai, Lixiong Ye, Lisong Sun, Xiaoshuai Enoch, Obeng Hu, Rongdang Zan, Xingjie Lin, Feng Shen, Jianliang |
author_facet | He, Xiaojun Dai, Lixiong Ye, Lisong Sun, Xiaoshuai Enoch, Obeng Hu, Rongdang Zan, Xingjie Lin, Feng Shen, Jianliang |
author_sort | He, Xiaojun |
collection | PubMed |
description | Pathogenic bacteria infection is a serious threat to human public health due to the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option to improve the efficiency compared to conventional therapeutic agents. In addition to the drug loading capacity of nanocarriers, which is typically around 10%, further lowers the drug dose that pathological bacteria are exposed to. Moreover, nanocarriers that are not eliminated from the body may cause side effects. These limitations have motivated the development of self‐delivery systems that are formed by the self‐assembly of different therapeutic agents. In this study, a vehicle‐free antimicrobial polymer polyhexamethylene biguanide (PHMB, with bactericidal and anti‐biofilm functions) hybrid gold nanoparticle (Au NPs, with photothermal therapy (PTT)) platform (PHMB@Au NPs) is developed. This platform exhibits an excellent synergistic effect to enhance the photothermal bactericidal effect for Staphylococcus aureus under near‐infrared irradiation. Furthermore, the results showed that PHMB@Au NPs inhibit the formation of biofilms, quickly remove bacteria to promote wound healing through PTT in infection model in vivo, and even mediate the transition of macrophages from M1 to M2 type, and accelerate tissue angiogenesis. PHMB@Au NPs will have promising value as highly effective antimicrobial agents for patient management. |
format | Online Article Text |
id | pubmed-9108595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91085952022-05-20 A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing He, Xiaojun Dai, Lixiong Ye, Lisong Sun, Xiaoshuai Enoch, Obeng Hu, Rongdang Zan, Xingjie Lin, Feng Shen, Jianliang Adv Sci (Weinh) Research Articles Pathogenic bacteria infection is a serious threat to human public health due to the high morbidity and mortality rates. Nano delivery system for delivering antibiotics provides an alternative option to improve the efficiency compared to conventional therapeutic agents. In addition to the drug loading capacity of nanocarriers, which is typically around 10%, further lowers the drug dose that pathological bacteria are exposed to. Moreover, nanocarriers that are not eliminated from the body may cause side effects. These limitations have motivated the development of self‐delivery systems that are formed by the self‐assembly of different therapeutic agents. In this study, a vehicle‐free antimicrobial polymer polyhexamethylene biguanide (PHMB, with bactericidal and anti‐biofilm functions) hybrid gold nanoparticle (Au NPs, with photothermal therapy (PTT)) platform (PHMB@Au NPs) is developed. This platform exhibits an excellent synergistic effect to enhance the photothermal bactericidal effect for Staphylococcus aureus under near‐infrared irradiation. Furthermore, the results showed that PHMB@Au NPs inhibit the formation of biofilms, quickly remove bacteria to promote wound healing through PTT in infection model in vivo, and even mediate the transition of macrophages from M1 to M2 type, and accelerate tissue angiogenesis. PHMB@Au NPs will have promising value as highly effective antimicrobial agents for patient management. John Wiley and Sons Inc. 2022-03-10 /pmc/articles/PMC9108595/ /pubmed/35274475 http://dx.doi.org/10.1002/advs.202105223 Text en © 2022 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles He, Xiaojun Dai, Lixiong Ye, Lisong Sun, Xiaoshuai Enoch, Obeng Hu, Rongdang Zan, Xingjie Lin, Feng Shen, Jianliang A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing |
title | A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing |
title_full | A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing |
title_fullStr | A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing |
title_full_unstemmed | A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing |
title_short | A Vehicle‐Free Antimicrobial Polymer Hybrid Gold Nanoparticle as Synergistically Therapeutic Platforms for Staphylococcus aureus Infected Wound Healing |
title_sort | vehicle‐free antimicrobial polymer hybrid gold nanoparticle as synergistically therapeutic platforms for staphylococcus aureus infected wound healing |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108595/ https://www.ncbi.nlm.nih.gov/pubmed/35274475 http://dx.doi.org/10.1002/advs.202105223 |
work_keys_str_mv | AT hexiaojun avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT dailixiong avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT yelisong avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT sunxiaoshuai avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT enochobeng avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT hurongdang avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT zanxingjie avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT linfeng avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT shenjianliang avehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT hexiaojun vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT dailixiong vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT yelisong vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT sunxiaoshuai vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT enochobeng vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT hurongdang vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT zanxingjie vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT linfeng vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing AT shenjianliang vehiclefreeantimicrobialpolymerhybridgoldnanoparticleassynergisticallytherapeuticplatformsforstaphylococcusaureusinfectedwoundhealing |