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The intrinsically disordered CARDs‐Helicase linker in RIG‐I is a molecular gate for RNA proofreading

The innate immune receptor RIG‐I provides a first line of defense against viral infections. Viral RNAs are recognized by RIG‐I's C‐terminal domain (CTD), but the RNA must engage the helicase domain to release the signaling CARD (Caspase Activation and Recruitment Domain) domains from their auto...

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Detalles Bibliográficos
Autores principales:	Schweibenz, Brandon D, Devarkar, Swapnil C, Solotchi, Mihai, Craig, Candice, Zheng, Jie, Pascal, Bruce D, Gokhale, Samantha, Xie, Ping, Griffin, Patrick R, Patel, Smita S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108607/ https://www.ncbi.nlm.nih.gov/pubmed/35437807 http://dx.doi.org/10.15252/embj.2021109782

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