MYPT1/PP1‐Mediated EZH2 Dephosphorylation at S21 Promotes Epithelial–Mesenchymal Transition in Fibrosis through Control of Multiple Families of Genes

The methyltransferase EZH2 plays an important role in regulating chromatin conformation and gene transcription. Phosphorylation of EZH2 at S21 by AKT kinase suppresses its function. However, protein phosphatases responsible for the dephosphorylation of EZH2‐S21 remain elusive. Here, it is demonstrat...

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Detalles Bibliográficos
Autores principales: Zhang, Lan, Wang, Ling, Hu, Xue‐Bin, Hou, Min, Xiao, Yuan, Xiang, Jia‐Wen, Xie, Jie, Chen, Zhi‐Gang, Yang, Tian‐Heng, Nie, Qian, Fu, Jia‐Ling, Wang, Yan, Zheng, Shu‐Yu, Liu, Yun‐Fei, Gan, Yu‐Wen, Gao, Qian, Bai, Yue‐Yue, Wang, Jing‐Miao, Qi, Rui‐Li, Zou, Ming, Ke, Qin, Zhu, Xing‐Fei, Gong, Lili, Liu, Yizhi, Li, David Wan‐Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108659/
https://www.ncbi.nlm.nih.gov/pubmed/35293697
http://dx.doi.org/10.1002/advs.202105539

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