A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to lear...

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Autores principales: Jamison, David A., Anand Narayanan, S., Trovão, Nídia S., Guarnieri, Joseph W., Topper, Michael J., Moraes-Vieira, Pedro M., Zaksas, Viktorija, Singh, Keshav K., Wurtele, Eve Syrkin, Beheshti, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
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Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108708/
https://www.ncbi.nlm.nih.gov/pubmed/35577935
http://dx.doi.org/10.1038/s41431-022-01108-8
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author Jamison, David A.
Anand Narayanan, S.
Trovão, Nídia S.
Guarnieri, Joseph W.
Topper, Michael J.
Moraes-Vieira, Pedro M.
Zaksas, Viktorija
Singh, Keshav K.
Wurtele, Eve Syrkin
Beheshti, Afshin
author_facet Jamison, David A.
Anand Narayanan, S.
Trovão, Nídia S.
Guarnieri, Joseph W.
Topper, Michael J.
Moraes-Vieira, Pedro M.
Zaksas, Viktorija
Singh, Keshav K.
Wurtele, Eve Syrkin
Beheshti, Afshin
author_sort Jamison, David A.
collection PubMed
description COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.
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spelling pubmed-91087082022-05-16 A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection Jamison, David A. Anand Narayanan, S. Trovão, Nídia S. Guarnieri, Joseph W. Topper, Michael J. Moraes-Vieira, Pedro M. Zaksas, Viktorija Singh, Keshav K. Wurtele, Eve Syrkin Beheshti, Afshin Eur J Hum Genet Review Article COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients. Springer International Publishing 2022-05-16 2022-08 /pmc/articles/PMC9108708/ /pubmed/35577935 http://dx.doi.org/10.1038/s41431-022-01108-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Jamison, David A.
Anand Narayanan, S.
Trovão, Nídia S.
Guarnieri, Joseph W.
Topper, Michael J.
Moraes-Vieira, Pedro M.
Zaksas, Viktorija
Singh, Keshav K.
Wurtele, Eve Syrkin
Beheshti, Afshin
A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
title A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
title_full A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
title_fullStr A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
title_full_unstemmed A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
title_short A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
title_sort comprehensive sars-cov-2 and covid-19 review, part 1: intracellular overdrive for sars-cov-2 infection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108708/
https://www.ncbi.nlm.nih.gov/pubmed/35577935
http://dx.doi.org/10.1038/s41431-022-01108-8
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