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Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein

BACKGROUND: The Transmembrane Serine Protease 2 (TMPRSS2) of human cell plays a significant role in proteolytic cleavage of SARS-Cov-2 coronavirus spike protein and subsequent priming to the receptor ACE2. Approaching TMPRSS2 as a therapeutic target for the inhibition of SARS-Cov-2 infection is high...

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Detalles Bibliográficos
Autores principales:	Manjunathan, Reji, Periyaswami, Vijayalakshmi, Mitra, Kartik, Rosita, Arokiaraj Sherlin, Pandya, Medha, Selvaraj, Jayaraman, Ravi, Lokesh, Devarajan, Nalini, Doble, Mukesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108711/ https://www.ncbi.nlm.nih.gov/pubmed/35578172 http://dx.doi.org/10.1186/s12859-022-04724-9

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