Intranasal Midazolam Premedication for Anxiolysis in Children Reluctant to Receive Nitrous Oxide Sedation via Nasal Hood: An In Vivo Randomized Control Trial

AIM AND OBJECTIVE: The aim of the study was to compare administration of 0.1 mg/kg intranasal midazolam as premedication against a normal saline control in alleviating anxiety relating to and increasing acceptance of nasal hood by child patients receiving nitrous oxide sedation. MATERIALS AND METHODS: After ethical clearance and informed consent, on the basis of odd and even numbers patients were allocated to group midazolam (group M) or group normal saline (group N), respectively. The physical parameters were recorded at the beginning and after the procedure; time required for the procedure was also recorded. The level of cooperation during acceptance of the nasal mask by the patient was evaluated using the four-point scale. RESULT: Group M (midazolam premedication) was more effective in improving the acceptance of the nasal hood in children than the normal saline/traditional/conventional method of treating the teeth. The p -value is .002308. CONCLUSION: In the present study the combination of midazolam and nitrous oxide proved to be an effective combination, resulting in good to excellent behavior in children who were Frankl's behavior rating definitely negative and negative. CLINICAL SIGNIFICANCE: For successful sedation premedication with nitrous oxide, midazolam is an excellent premedication drug. HOW TO CITE THIS ARTICLE: Musani I, Bhure S, Choubey S, et al. Intranasal Midazolam Premedication for Anxiolysis in Children Reluctant to Receive Nitrous Oxide Sedation via Nasal Hood: An In Vivo Randomized Control Trial. Int J Clin Pediatr Dent 2021;14(S-2):S138-S142.