Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

AMP-activated protein kinase (AMPK) is a central energy sensor that coordinates the response to energy challenges to maintain cellular ATP levels. AMPK is a potential therapeutic target for treating metabolic disorders, and several direct synthetic activators of AMPK have been developed that show pr...

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Detalles Bibliográficos
Autores principales: Sanders, Matthew J., Ratinaud, Yann, Neopane, Katyayanee, Bonhoure, Nicolas, Day, Emily A., Ciclet, Olivier, Lassueur, Steve, Naranjo Pinta, Martine, Deak, Maria, Brinon, Benjamin, Christen, Stefan, Steinberg, Gregory R., Barron, Denis, Sakamoto, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108889/
https://www.ncbi.nlm.nih.gov/pubmed/35331736
http://dx.doi.org/10.1016/j.jbc.2022.101852

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