Mitogen-activated protein kinase phosphatase-1 controls PD-L1 expression by regulating type I interferon during systemic Escherichia coli infection

Mitogen-activated protein kinase phosphatase 1 (Mkp-1) KO mice produce elevated cytokines and exhibit increased mortality and bacterial burden following systemic Escherichia coli infection. To understand how Mkp-1 affects immune defense, we analyzed the RNA-Seq datasets previously generated from con...

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Detalles Bibliográficos
Autores principales: Barley, Timothy J., Murphy, Parker R., Wang, Xiantao, Bowman, Bridget A., Mormol, Justin M., Mager, Carli E., Kirk, Sean G., Cash, Charles J., Linn, Sarah C., Meng, Xiaomei, Nelin, Leif D., Chen, Bernadette, Hafner, Markus, Zhang, Jian, Liu, Yusen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108994/
https://www.ncbi.nlm.nih.gov/pubmed/35429501
http://dx.doi.org/10.1016/j.jbc.2022.101938

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