Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment

Liver transplantation (LT) is the only curative therapy in patients with end-stage liver disease. Long-term survival is excellent, yet LT recipients are at risk of significant complications. Biliary complications are an important source of morbidity after LT, with an estimated incidence of 5%–32%. P...

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Autores principales: Fasullo, Matthew, Patel, Milan, Khanna, Lauren, Shah, Tilak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Biliary Tract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109012/
https://www.ncbi.nlm.nih.gov/pubmed/35552193
http://dx.doi.org/10.1136/bmjgast-2021-000778
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author Fasullo, Matthew
Patel, Milan
Khanna, Lauren
Shah, Tilak
author_facet Fasullo, Matthew
Patel, Milan
Khanna, Lauren
Shah, Tilak
author_sort Fasullo, Matthew
collection PubMed
description Liver transplantation (LT) is the only curative therapy in patients with end-stage liver disease. Long-term survival is excellent, yet LT recipients are at risk of significant complications. Biliary complications are an important source of morbidity after LT, with an estimated incidence of 5%–32%. Post-LT biliary complications include strictures (anastomotic and non-anastomotic), bile leaks, stones, and sphincter of Oddi dysfunction. Prompt recognition and management is critical as these complications are associated with mortality rates up to 20% and retransplantation rates up to 13%. This review aims to summarise our current understanding of risk factors, natural history, diagnostic testing, and treatment options for post-transplant biliary complications.
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spelling pubmed-91090122022-05-27 Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment Fasullo, Matthew Patel, Milan Khanna, Lauren Shah, Tilak BMJ Open Gastroenterol Biliary Tract Liver transplantation (LT) is the only curative therapy in patients with end-stage liver disease. Long-term survival is excellent, yet LT recipients are at risk of significant complications. Biliary complications are an important source of morbidity after LT, with an estimated incidence of 5%–32%. Post-LT biliary complications include strictures (anastomotic and non-anastomotic), bile leaks, stones, and sphincter of Oddi dysfunction. Prompt recognition and management is critical as these complications are associated with mortality rates up to 20% and retransplantation rates up to 13%. This review aims to summarise our current understanding of risk factors, natural history, diagnostic testing, and treatment options for post-transplant biliary complications. BMJ Publishing Group 2022-05-11 /pmc/articles/PMC9109012/ /pubmed/35552193 http://dx.doi.org/10.1136/bmjgast-2021-000778 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Biliary Tract
Fasullo, Matthew
Patel, Milan
Khanna, Lauren
Shah, Tilak
Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
title Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
title_full Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
title_fullStr Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
title_full_unstemmed Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
title_short Post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
title_sort post-transplant biliary complications: advances in pathophysiology, diagnosis, and treatment
topic Biliary Tract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109012/
https://www.ncbi.nlm.nih.gov/pubmed/35552193
http://dx.doi.org/10.1136/bmjgast-2021-000778
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